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临床试验/NCT05256212
NCT05256212已完成不适用

Occupational Exposure of Firefighters to Environmental Pollutants

Assaf-Harofeh Medical Center1 个研究点 分布在 1 个国家目标入组 108 人开始时间: 2017年8月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
108
试验地点
1
主要终点
BTEX levels, measured in urine by LC-MS/MS

研究概览

简要总结

The aim of the current trial is to assess the exposure of firefighters (FF) to environmental pollutants emitted from fires, to explore the association of exposure with their health status and to compare these data with those of non-FF participants

详细描述

Occupational exposure of firefighters to environmental contaminants Background Firefighters (FF) are exposed during their firefighting activities to a vast array of contaminants and toxic gases vapors that are released into the environment as results of combustion. Between those materials, there are heavy metals, brominated flame retardants (Polybrominated diphenyl ethers, PBDEs) and Volatile organic Compounds (VOC) that include between others Benzene, Toluene, Ethylbenzene and Xylene (BTEX).In the last decade a concern for negative health impact for all these contaminants appeared.

There is a vast use of these materials in the production of cars, furniture, electrical appliances, mattresses, paints, etc. These materials are released into the environment and absorbed by the human body.

There are some groups with increased exposure to these materials in comparison to the general population, as results of occupational exposure. Some of these groups include FF, workers who recycle electronic equipment and furniture manufacture workers.

Purposes:

  1. to measure the levels of PBDEs, heavy metals and BTEX metabolites in the blood and urine of FF who are exposed to fires during their work
  2. to evaluate the association between the levels of these materials and the health status of the participants. This will be done using a health questionnaire and the results of blood tests showing liver, renal and thyroid functions.
  3. to compare their exposure levels and health status with those of general population

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
Male
接受健康志愿者

入选标准

  • * active firefighters

排除标准

  • firefighters with known liver, renal or thyroid problems

结局指标

主要结局

BTEX levels, measured in urine by LC-MS/MS

时间窗: Day 1- day of recruitment

to test for BTEX levels in blood

PBDEs levels, measured in serum by GC-MS

时间窗: Day 1- day of recruitment

to test for PBDE levels in blood

Heavy metals (Pb, Hg, Cd) levels, measured in urine by ICP-MS

时间窗: Day 1- day of recruitment

to test for Heavy metals levels

次要结局

  • Thyroid function (TSH or FT4 out of lab reference values) measured in serum(Day 1- day of recruitment)
  • Liver enzymes levels (x2 of Upper Limit of Normal), measured in serum(Day 1- day of recruitment)
  • renal function (eGFR<60), by creatinine level measured in serum(Day 1- day of recruitment)

研究者

申办方类型
Other Gov
责任方
Principal Investigator
主要研究者

Elkana Kohn

Head of Research- Clinical Pharmacology and Toxicology

Assaf-Harofeh Medical Center

研究点 (1)

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