Occupational Exposure of Firefighters to Environmental Pollutants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 108
- 试验地点
- 1
- 主要终点
- BTEX levels, measured in urine by LC-MS/MS
研究概览
简要总结
The aim of the current trial is to assess the exposure of firefighters (FF) to environmental pollutants emitted from fires, to explore the association of exposure with their health status and to compare these data with those of non-FF participants
详细描述
Occupational exposure of firefighters to environmental contaminants Background Firefighters (FF) are exposed during their firefighting activities to a vast array of contaminants and toxic gases vapors that are released into the environment as results of combustion. Between those materials, there are heavy metals, brominated flame retardants (Polybrominated diphenyl ethers, PBDEs) and Volatile organic Compounds (VOC) that include between others Benzene, Toluene, Ethylbenzene and Xylene (BTEX).In the last decade a concern for negative health impact for all these contaminants appeared.
There is a vast use of these materials in the production of cars, furniture, electrical appliances, mattresses, paints, etc. These materials are released into the environment and absorbed by the human body.
There are some groups with increased exposure to these materials in comparison to the general population, as results of occupational exposure. Some of these groups include FF, workers who recycle electronic equipment and furniture manufacture workers.
Purposes:
- to measure the levels of PBDEs, heavy metals and BTEX metabolites in the blood and urine of FF who are exposed to fires during their work
- to evaluate the association between the levels of these materials and the health status of the participants. This will be done using a health questionnaire and the results of blood tests showing liver, renal and thyroid functions.
- to compare their exposure levels and health status with those of general population
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •* active firefighters
排除标准
- •firefighters with known liver, renal or thyroid problems
结局指标
主要结局
BTEX levels, measured in urine by LC-MS/MS
时间窗: Day 1- day of recruitment
to test for BTEX levels in blood
PBDEs levels, measured in serum by GC-MS
时间窗: Day 1- day of recruitment
to test for PBDE levels in blood
Heavy metals (Pb, Hg, Cd) levels, measured in urine by ICP-MS
时间窗: Day 1- day of recruitment
to test for Heavy metals levels
次要结局
- Thyroid function (TSH or FT4 out of lab reference values) measured in serum(Day 1- day of recruitment)
- Liver enzymes levels (x2 of Upper Limit of Normal), measured in serum(Day 1- day of recruitment)
- renal function (eGFR<60), by creatinine level measured in serum(Day 1- day of recruitment)
研究者
Elkana Kohn
Head of Research- Clinical Pharmacology and Toxicology
Assaf-Harofeh Medical Center
