Extra energy for hearts with a genetic defect
Recruiting
- Conditions
- Hypertrophic Cardiomyopathy
- Registration Number
- NL-OMON25078
- Lead Sponsor
- ZonMW en de Hartstichting, Programma Translationeel Onderzoek, project 95105003
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
18-65 years old
Class 5 MYH7 mutation identified by pre-symptomatic genetic screening
Exclusion Criteria
Cardiovascular disease
- Hypertrophic Cardiomyopathy (Maximal Wall Thickness >15mm)
- Wall motion disorders
Diabetes mellitus
Any absolute or relative contra-indication for MRI (i.e. metallic implants and claustrophobia)
Inability to give informed consent.
Severely impaired renal function with a GFR < 30 ml/min
Parkinson disease and related symptoms
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Myocardial energy efficiency, as measured by PET/CT and CMR
- Secondary Outcome Measures
Name Time Method Diastolic function measured by echocardiography, volume parameters of the heart measured by CMR, exercise capacity measured by CPET, electrophysiological properties of the heart measured by ECG