Study of Clinical Features of Patients With Autoimmune Liver Disease Complicated With Covid-19 and the Immune Mechanism Affecting Prognosis

Active, not recruiting

• Conditions: Autoimmune Liver Disease, COVID-19
• Interventions: Other: Different types of disease

• Registration Number: NCT06099626
• Lead Sponsor: The Second Affiliated Hospital of Chongqing Medical University

Brief Summary

With the decreasing virulence of omicrons strain, the current domestic epidemic prevention policy has been changed based on the health of the people and the development needs of the country. At present, the infection rate of the novel coronavirus in China is rising rapidly. Previous studies have found that patients with chronic liver disease are more likely to be co-infected with coronavirus disease 2019 and have a worse prognosis. Based on its unique immune mechanism and therapeutic drugs, patients with autoimmune liver disease also have very different manifestations after infection with the novel coronavirus. By observing the clinical characteristics and prognosis of patients with autoimmune liver disease complicated with coronavirus disease 2019, this study analyzed the roles of vaccines, immunosuppressive agents and ursodeoxycholic acid , and explored the immune mechanism behind them, so as to seek new anti-coronavirus disease 2019 drugs and provide new strategies for clinical prevention and treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Status Verified: 2023-08
• Study First Submitted: 2023-10-23
• Study First Submitted QC: 2023-10-23
• Last Update Submitted: 2023-10-23
• Study First Posted: 2023-10-25
• Last Update Posted: 2023-10-25
• Primary Completion: 2024-06-30
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
A:autoimmune hepatitis	Different types of disease	-
C:/primary biliary cirrhosis	Different types of disease	-
B:autoimmune hepatitis/primary biliary cirrhosis	Different types of disease	-
E	Different types of disease	Subjects who have no previous history of COVID-19 infection and have been vaccinated against COVID-19.
D:Subjects tested positive for COVID-19 antigen or COVID-19 nucleic acid	Different types of disease	-

Primary Outcome Measures

Name	Time	Method
Clinical features and prognosis	6 months	clinical manifestation,antibody titer

Trial Locations

Locations (1)

Dazhi Zhang; 🇨🇳 Chongqing, Chongqing, China