The impact of caloric restriction versus exercise on tumor and muscle tissue protein synthesis rates in breast cancer patients

Completed

• Conditions: Breast cancer; muscle; 10006291

• Registration Number: NL-OMON56422
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

1) Female
2) BMI 18.5-35.0 kg/m2
3) Diagnosed with breast cancer, with treatment requiring a lumpectomy

Exclusion Criteria

1) Patients receiving preoperative chemo- or radio-therapy
2) >5% weight loss in the previous 6 months
3) Fasting glucose >7 mmol/L
4) Musculoskeletal injuries (which may interfere with performing the exercise
program)
5) Participation in structured resistance exercise program
6) A history of neuromuscular problems
7) Use of anti-coagulants
8) Use of protein and/or fish-oil supplements
9) Participation in a 2H2O study in the previous 6 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Tumor tissue protein synthesis rates over the 7-day intervention period in<br /><br>breast cancer patients.<br /><br>2. Muscle tissue protein synthesis rates over the 7-day intervention period in<br /><br>breast cancer patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Healthy breast tissue protein synthesis rates over the 7-day intervention<br /><br>period. Plasma concentrations of estrogen, insulin, growth hormone, IGF-1,<br /><br>IGFBP-1, IGFBP-3, C-reactive protein, IL-1, IL-6, TNF-alpha, IL-10.</p><br>