The impact of caloric restriction versus exercise on tumor and muscle tissue protein synthesis rates in breast cancer patients
Recruiting
- Conditions
- Breast Cancer
- Registration Number
- NL-OMON25682
- Lead Sponsor
- Maastricht University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
1) Female
2) BMI 20-35.0 kg/m2
3) Diagnosed with breast cancer, with treatment requiring a lumpectomy or mastectomy
Exclusion Criteria
1)Patients receiving preoperative chemo- or radio-therapy
2)>5% weight loss in the previous 6 months
3)Fasting glucose >7 mmol/L
4)Musculoskeletal injuries (which may interfere with performing the exercise program)
5)Participation in structured resistance exercise program
6)A history of neuromuscular problems
7)Use of anti-coagulants
8)Use of protein and/or fish-oil supplements
9)Participation in a 2H2O study in the previous 6 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Tumor tissue protein synthesis rates over the 7-day intervention period in breast cancer patients.<br>2. Muscle tissue protein synthesis rates over the 7-day intervention period in breast cancer patients.
- Secondary Outcome Measures
Name Time Method Differences between intervention groups in concentrations of circulating anabolic hormones (e.g., estrogen, insulin, growth hormone), growth factors (e.g., IGF-1, IGFBP-1, IGFBP-3), and (pro- and anti-inflammatory) cytokines (e.g., C-reactive protein, IL-1, IL-6, TNF-alpha, IL-10).