Ultrasound-guided Continuous Low Serratus Anterior Plane Block in Hepatocellular Carcinoma Surgery

Not Applicable

Recruiting

• Conditions: Liver Neoplasms; Serratus Anterior Plane Block; Postoperative Analgesia
• Interventions: Procedure: Ultrasound-guided single serratus anterior plane block; Procedure: Ultrasound-guided continuous low serratus anterior plane block

• Registration Number: NCT05531864
• Lead Sponsor: Liu Di

Brief Summary

To investigate the clinical application of ultrasound-guided continuous low serratus anterior plane block in open surgery for hepatocellular carcinoma.

Detailed Description

METHODS: Patients with hepatocellular carcinoma who attended our hospital from January 2021 to April 2023 were divided into CS group and N group according to the random number table method; CS group underwent ultrasound-guided continuous low anterior serratus plane block and N group underwent ultrasound-guided single anterior serratus plane block combined with rectus abdominis sheath block; the operation time, anesthesia time, incision length, sensory block time and sensory block maintenance time were counted and recorded. Pain score (NRS) was used to detect analgesia; alanine aminotransferase (ALT), liver function aspartate aminotransferase (AST), and prothrombin time (The time of thrombin, NRS) were measured by fluorescent quantitative PCR. （The time of thrombin (APTT), total bilirubin (TBIL) levels and adverse reactions.

Study Timeline

• Study Start: 2021-01-01
• Study First Submitted: 2022-08-25
• Study First Submitted QC: 2022-09-03
• Study First Posted: 2022-09-08
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-26
• Last Update Posted: 2024-02-28
• Primary Completion: 2024-02-29
• Study Completion: 2024-02-29

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

1. Age 18-60 years;
2. ASAI-II;
3. BMI: 18-29 kg/m2

Exclusion Criteria

1. Combined cardiac, cerebral, hepatic, and renal failure;
2. Comorbid psychiatric and neuromuscular disorders;
3. A history of allergy to anesthetic drugs;
4. Participation in other recent clinical or drug trials.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Single serratus anterior plane block combined with rectus sheath nerve block	Ultrasound-guided single serratus anterior plane block	Ultrasound-guided single serratus anterior plane block combined with rectus sheath nerve block.
Continuous serratus anterior plane block	Ultrasound-guided continuous low serratus anterior plane block	Ultrasound-guided continuous serratus anterior plane block.

Primary Outcome Measures

Name	Time	Method
visual analogue scale	36 hours after surgery.	The visual analogue scale (VAS) of the patient's pain was recorded 36 hours after operation.
Block plane	30 minute after the surgery begins	The effect of anesthesia after ultrasound-guided nerve block was measured using planimetry, as well as the area being anesthetized. The chest wall between T2-T9 and ice cotton balls was used to assess the extent and extent of anesthesia block.

Secondary Outcome Measures

Name	Time	Method
Intraoperative blood pressure changes	2 hours after the beginning of surgery.	Blood pressure changes were measured directly by radial artery puncture and recorded.; The changes in blood pressure and heart rate before and after excision and the use of intraoperative opioids.
Patient satisfaction	48 hours after surgery.	The patient's satisfaction with the analgesia 2 days after surgery was recorded. The analgesic effect: 1-3 as satisfactory, 4-6 as unsatisfactory, 7-10 as ineffective
Remedial analgesic drug	24 hours after surgery.	Whether other analgesic drugs were added within 24 hours after operation was recorded
Intraoperative heart rate changes	2 hours after the beginning of surgery.	The curve of the change of the operative heart rate was recorded through the anesthesia machine.

Trial Locations

Locations (1)

The First People's Hospital of Neijiang; 🇨🇳 Neijiang, Sichuan, China