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Ultrasound-guided Continuous Low Serratus Anterior Plane Block in Hepatocellular Carcinoma Surgery

Not Applicable
Recruiting
Conditions
Liver Neoplasms
Serratus Anterior Plane Block
Postoperative Analgesia
Registration Number
NCT05531864
Lead Sponsor
Liu Di
Brief Summary

To investigate the clinical application of ultrasound-guided continuous low serratus anterior plane block in open surgery for hepatocellular carcinoma.

Detailed Description

METHODS: Patients with hepatocellular carcinoma who attended our hospital from January 2021 to April 2023 were divided into CS group and N group according to the random number table method; CS group underwent ultrasound-guided continuous low anterior serratus plane block and N group underwent ultrasound-guided single anterior serratus plane block combined with rectus abdominis sheath block; the operation time, anesthesia time, incision length, sensory block time and sensory block maintenance time were counted and recorded. Pain score (NRS) was used to detect analgesia; alanine aminotransferase (ALT), liver function aspartate aminotransferase (AST), and prothrombin time (The time of thrombin, NRS) were measured by fluorescent quantitative PCR. (The time of thrombin (APTT), total bilirubin (TBIL) levels and adverse reactions.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
160
Inclusion Criteria
  1. Age 18-60 years;
  2. ASAI-II;
  3. BMI: 18-29 kg/m2
Exclusion Criteria
  1. Combined cardiac, cerebral, hepatic, and renal failure;
  2. Comorbid psychiatric and neuromuscular disorders;
  3. A history of allergy to anesthetic drugs;
  4. Participation in other recent clinical or drug trials.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
visual analogue scale36 hours after surgery.

The visual analogue scale (VAS) of the patient's pain was recorded 36 hours after operation.

Block plane30 minute after the surgery begins

The effect of anesthesia after ultrasound-guided nerve block was measured using planimetry, as well as the area being anesthetized. The chest wall between T2-T9 and ice cotton balls was used to assess the extent and extent of anesthesia block.

Secondary Outcome Measures
NameTimeMethod
Intraoperative blood pressure changes2 hours after the beginning of surgery.

Blood pressure changes were measured directly by radial artery puncture and recorded.

The changes in blood pressure and heart rate before and after excision and the use of intraoperative opioids.

Patient satisfaction48 hours after surgery.

The patient's satisfaction with the analgesia 2 days after surgery was recorded. The analgesic effect: 1-3 as satisfactory, 4-6 as unsatisfactory, 7-10 as ineffective

Remedial analgesic drug24 hours after surgery.

Whether other analgesic drugs were added within 24 hours after operation was recorded

Intraoperative heart rate changes2 hours after the beginning of surgery.

The curve of the change of the operative heart rate was recorded through the anesthesia machine.

Trial Locations

Locations (1)

The First People's Hospital of Neijiang

🇨🇳

Neijiang, Sichuan, China

The First People's Hospital of Neijiang
🇨🇳Neijiang, Sichuan, China
Hengchun Shen, master
Contact
15599237557

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