Etomidate Induction in Hysteroscopic Surgery

Not Applicable

• Conditions: Etomidate Induced Dose; Hysteroscopic Surgery
• Interventions: Drug: etomidate; Drug: propofol

• Registration Number: NCT05520645
• Lead Sponsor: Peking University Third Hospital

Brief Summary

This study intends to study the optimal dose induced by etomidate in outpatients undergoing painless hysteroscopic surgery. At present, the dosage in the user manual is 0.1-0.3mg/kg. In clinical use, it is found that 0.1mg/kg often fails to achieve sedative effect, and 0.3mg/kg is prone to muscle twitching. Therefore, three groups of doses of 0.15mg/kg, 0.2mg/kg and 0.25mg/kg are set. It is hoped that this study will provide a basis for clinical evaluation of etomidate in anesthesia induction of hysteroscopic surgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-08
• Study First Submitted: 2022-08-19
• Study Start: 2022-08-25
• Study First Submitted QC: 2022-08-29
• Last Update Submitted: 2022-08-29
• Study First Posted: 2022-08-30
• Last Update Posted: 2022-08-30
• Primary Completion: 2023-09-30
• Study Completion: 2023-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

Patients to undergo hysteroscopic surgery

Exclusion Criteria

Hemo-dynamically unstable patients Allergic to egg protein Patients with epilepsy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Eto 0.15mg/kg	etomidate	Etomidate 0.15mg/kg for anesthesia induction
Eto 0.25mg/kg	etomidate	Etomidate 0.25mg/kg for anesthesia induction
Propofol 2mg/kg	propofol	propofol 2mg/kg for anesthesia induction
Eto 0.2mg/kg	etomidate	Etomidate 0.2mg/kg for anesthesia induction

Primary Outcome Measures

Name	Time	Method
Mean Arterial Pressure	Change in Mean Arterial Pressure(MAP) in mm of Hg from baseline value every 5 minutes for 30 minutes	Mean value of Mean Arterial Pressures
Heart rate per minute	Change in Heart rate per minute from baseline value every five minutes for 30 minutes	Mean of Heart rate per minute at above mentioned time intervals was measured and any study drug causing bradycardia

Secondary Outcome Measures

Name	Time	Method
Myoclonic movements	60 seconds after injection of study drug	% of cases with Myoclonic movements
Post Operative Nausea and Vomiting	Throughout entire study estimated to take 1 month to complete	% of cases with any treatment for Post Operative Nausea and Vomiting
any oxygen saturation event below 85% by pulse oximetry	Throughout entire study estimated to take 1 month to complet	% of cases with any oxygen saturation event below 85% by pulse oximetry