Magnetic Resonance Imaging Study of Acute Pancreatitis

Completed

Conditions: Acute Pancreatitis

Registration Number: NCT01911689

Lead Sponsor: Afﬁliated Hospital of North Sichuan Medical College

Brief Summary: To quantitatively analyze the T2\* values of the head, body, and tail of normal pancreas, and observe the value of GRE T2\*-weighted MRI in the diagnosis of acute pancreatitis and the relationship between the T2\* value and the severity of AP.

Detailed Description: 1. We design a prospective study about "Magetic Resonance Imaging Study of Acute Pancreatitis".

2. We apply for an account and register our study on the clinicalTrials.

3. In patients with acute pancreatitis, imaging is recommended to confirm the clinical diagnosis, investigate the etiology, and grade the severity of the disease . MR had the excellent resolution of soft tissue，and it has earned an ever more important role in the diagnosis of AP. With the continuous development of MR scanning techniques, the sequence of a multi-echo gradient recalled echo (GRE) T2\*-weighted imaging (T2\*WI), which acquires a spin echo signal, T2\* relaxation acquires a gradient echo signal, is a relatively new MRI technique. The sequence of a GRE T2\*WI requires high uniformity of the magnetic field, plus it can provide the T2\* value, which can indirectly reflect changes in tissue biochemical components, thus it can be used for the early diagnosis quantitative diagnosis of some diseases .

4. This calculation process for T2\* value is completed using post-processing software on the workstation(Advantage workstation 4.4; GE Halthcare) directly after scanning.

5. AP is a process of inflammation diffusion, in which cell edema will lead to hydrogen proton increase. In the inflammatory exudation process, T2\* value will change. So we conduct our research. In this study, we will observe pancreas in the normal pancreas and AP, and discuss the relationship between T2\* value and that of AP graded by the MR severity index (MRSI) and Acute Physiology And Chronic Healthy Evaluation II (APACHE II) scores.

6. However, until now, there is no research on the sequence applied in the patients with AP.

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 168

Inclusion Criteria

acute onset of abdominal pain;
pancreatitis at first onset;
three-fold elevated amylase or lipase, excluding other causes of elevated enzymes; and
abdominal MR examination.

Exclusion Criteria

inability to cooperate when MR imaging was performed;
a history of chronic pancreatitis;
AP due to pancreatic carcinoma;
hypoproteinemia;
with hypoproteinemia and other peritoneal/ retroperitoneal infection diseases ;
with iron deposition disorder (e.g. diabetes or blood system diseases).

Study & Design

Study Type: OBSERVATIONAL

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The T2* Values in the Diagnosis of AP	1 year	Compare the difference of the T2\* value between the AP group and the control group.

Secondary Outcome Measures

Name	Time	Method
The Relationship Between the T2* Value and the Severity of AP According to Apache II	1 year	In clinical practice, the physician usually used the APACHE II to evaluate the severity of acute pancreatitis. AP was graded as mild (0-7 points) and severe AP (≥8 points) according to the APACHE II scoring system.
The Difference of T2* Value Between the Edematous AP and Necrotizing AP	1 year	Compare the difference of the T2\* value between the edematous AP group and necrotizing AP group
The T2* Value in Different Severity of AP According to MRSI	1 year	AP was graded as mild (0-3 points), moderate (4-6 points) or severe (7-10 points), according to the MR-severity index (MRSI) which was derived from the CT-severity index .