Preservation of socket dimension after tooth removal by using bone graft and blood derived platelet concentrates

Completed

• Conditions: Type 1 extraction socket with buccal plate measuring greater than or equal to 1 mm and less than or equal to 3 mm in thickness with adjacent teeth in periodontal health; Disorder of gingiva and edentulousalveolar ridge, unspecified,

• Registration Number: CTRI/2021/06/034263
• Lead Sponsor: Government Dental college and Research InstituteBangalore

Brief Summary

Alveolar bone resorption that occurs after tooth loss yields diminished alveolar ridge dimensions.Alveolar ridge preservation(ARP)) aids the surgeon in achieving optimal placement of implant with desired implant diameter while maintaining the aesthetics of overlying tissues.Studies have revealed that grafting of the alveolus results in persistence of residual graft particles embedded into the newly formed bone delaying the rate of bone deposition and mineralization.To overcome this a simplified,novel technique was introduced,namely, Biologically Oriented Alveolar Ridge Preservation(BARP) for ARP that restricts socket grafting to the coronal portion of the socket.

Albumin-Platelet rich fibrin(Alb-PRF)  is prepared by mixing Heat treated platelet poor plasma(albumin gel)and the buffy coat layer(liquid PRF).This combination allows lower resorption properties of albumin gel along with higher cellular and growth factor content of the liquid PRF layer to be remixed.DFDBA has been shown to have osteoinductive potential and produce more vital bone.To our knowledge,no study has been conducted comparing the clinical efficacy of Biologically oriented alveolar ridge preservation (BARP) using DFDBA with Albumin-Platelet rich fibrin(Alb-PRF) biofiller ,DFDBA alone and naturally healing extraction socket with blood clot alone in extraction socket preservation.Hence this study is designed with the aim to evaluate and compare the efficacy of BARP using DFDBA with Alb-PRF biofiller, DFDBA alone and naturally healing extraction socket with blood clot alone in preserving alveolar ridge dimensions after tooth extraction.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-07
• Last Update Posted: 2024-07-31

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Male and female subjects of age 19-45yrs.
• ASA(American Society Of Anaesthetologists) Physical status 1.
• Hopeless or non-restorable single tooth indicated for extraction and future implant placement.
• Type 1 extraction socket with buccal plate measuring greater than or equal to 1 mm and less than or equal to 3 mm in thickness, with adjacent teeth in periodontal health.

Exclusion Criteria

• Subjects with compromised medical conditions contraindicating the surgical procedures.
• Subjects taking medication influencing the bone metabolism and bone healing.
• Subjects with the habit of smoking.
• Subjects with known metabolic disorders.
• Subjects in which tooth is extracted due to periodontal breakdown.
• Subjects with acute infection ( or presence of pus) in or close to the site intended for extraction.
• Pregnant and Lactating mothers.
• Subjects with poor oral hygiene.
• Subjects who are allergic to any of the materials used in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bone dimensional changes (bone height, bone width and bone mineral density) between the three groups as assessed by CBCT is set as the primary outcome	Bone dimensional changes (bone height, bone width and bone mineral density) from baseline to 4 months post-operatively between the three groups as assessed by CBCT is set as the primary outcome.

Secondary Outcome Measures

Name	Time	Method
1.Soft tissue healing index [Landry R, Turnbull R and Howley T, 1988].	2.Buccolingual ridge width using bone calipers

Trial Locations

Locations (1)

Government Dental college and research institute,Bangalore; 🇮🇳 Bangalore, KARNATAKA, India

Government Dental college and research institute,Bangalore

🇮🇳Bangalore, KARNATAKA, India

Dr Smitha K

Principal investigator

09449630572

periosmitha@gmail.com