ASER: assisted staphylococcal eradicatio
- Conditions
- Orthopaedic patients presenting for elective implant surgery that are colonised with S. aureusInfections and InfestationsStaphylococcal infection, unspecified site
- Registration Number
- ISRCTN28026496
- Lead Sponsor
- niversity of Edinburgh
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
1. Patient is scheduled for elective implant surgery
2. Patient is attending pre-operative assessment clinic within 8-21 days of planned surgery
3. Patient has confirmed nasal colonisation with S. aureus (MSSA or MRSA) after pre-operative assessment using a rapid PCR test for MRSA and MSSA
1. Patient with allergy or other contraindication to mupirocin or chlorhexidine treatment
2. Patient known to have mupirocin or chlorhexidine resistant SA
3. Patient unable to wait the 3-4 hours for the SA screening result
4. Patients in whom microbiological treatment for SA other than decolonisation is planned prior to hospital admission for surgery
5. Patients receiving antibiotics in the last 2 weeks or planned to receive antibiotics prior to surgery (excluding routine peri-operative antibiotic prophylaxis)
6. Patient scheduled to receive joint revision surgery due to infection
7. Patient lives too far from the hospital to be followed-up for microbiological sampling
8. Patient aged <16 years
9. Pregnancy or breastfeeding
10. No informed consent
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Current primary outcome measures as of 05/06/2017:<br>Proportion of participants cleared of nasal SA at 48-96 hours after completing current eradication regimens for S. aureus<br><br>Previous primary outcome measures:<br>Proportion of participants positive for nasal S. aureus 48-96 hours post eradication regimen as determined by microbial analysis
- Secondary Outcome Measures
Name Time Method