Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy diagnosis: a longitudinal study.
- Conditions
- PROGRESSIVE SUPRANUCLEAR PALSYMULTIPLE SYSTEM ATROPHYPARKINSON'S DISEASENeurological - Neurodegenerative diseasesNeurological - Parkinson's disease
- Registration Number
- ACTRN12612000119897
- Lead Sponsor
- A/Prof David Williams
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 65
Four groups to be recruited:
1. 20 People with Progressive Supranuclear Palsy as defined by National Institute of Neurological Diseases and Stroke criteria
2. 10 People with probable or possible Multiple System Atrophy according to published consensus criteria
3. 10 People with Parkinson's Disease according to Queens Square Brain Bank criteria
4. 10 normal controls
1.People with epilepsy
2.People with intracranial metal whith may increase the risk of seizures or injury due to Transcranial Magnetic Stimulation
3. People not able to complete clinical rating scales including cognitive assessment at baseline
4. Patients deemed not cabable of consenting to involvement in the study and for whom an appropriate person responsible is not available to participate in the consenting process
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Do measured responses in short interval cortical inhibition to theta burst stimulation correlate with clinical features as measured by physical and cognitive rating scales in Progressive Supranuclear Palsy.[Measured 6 monthly for 2 years]
- Secondary Outcome Measures
Name Time Method 2. Do Transcranial Magnetic Stimulation parameters distinguish between parkinsonian syndromes, ie. Progressive Supranuclear Palsy, Multiple System Atrophy and Parkinson's Disease.[Measured 6 monthly for 2 years]