Role of Oral Iron in Patients with Heart Failure and Iron Deficiency in Tanzania

Not Applicable

• Conditions: Circulatory System; Nutritional, Metabolic, Endocrine; Heart failure , iron deficiency

• Registration Number: PACTR201508001219405
• Lead Sponsor: Muhimbili University through SIDA-MUHAS capacity building Program

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-07-26
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 102

Inclusion Criteria

¿Diagnosis of stable heart failure (both with reduced and preserved EF) based on Echo and NT-proBNP >300 ng/L
¿Iron deficiency defined as: serum ferritin level <100 ¿g/L or 100 - 299 ¿g/L with concurrent transferrin saturation <20%.

Exclusion Criteria

¿Age < 18 years
¿Pregnant and lactating women
¿Documented/known stage III-IV liver disease;
¿Documented/known stage III-IV HIV disease;
¿Documented/known malignancy
¿Evidence of active bleeding
¿Known allergic or intolerant to Iron tablets
¿Already receiving or indicated for iron supplements
¿Received blood transfusion in the last 4 weeks
¿Documented/known hemolytic anaemia
¿Documented/known folate/B12 deficiency
¿Severe anaemia (<8g/dl),Or Hb>15g/dl
¿Consent is not given

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
increase in mean serum ferritin

Secondary Outcome Measures

Name	Time	Method
increase in mean left ventricular ejection fraction;dencrease in mean NT-ProBNP levels ;increase in mean hemoglobin;increase in mean 6-Minutes-Walk distance