Iron Status In Decompensated Heart Failure (IRON STATS-DHF)

Not Applicable

Completed

• Conditions: Topic: Cardiovascular disease; Subtopic: Cardiovascular (all Subtopics); Disease: Heart Failure; Circulatory System; Heart failure

• Registration Number: ISRCTN80063369
• Lead Sponsor: Portsmouth Hospitals NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-08-15
• Study Completion: 2015-02-16
• Last Update Posted: 8 June 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Study arm - acute decompensated heart failure (ADHF) patients:
1. Patients admitted with acute decompensated heart failure (defined as symptoms and signs secondary to abnormal cardiac function with weight gain of more than 3 kg above target weight or requiring intravenous diuretics for >48 hours).
2. Patients should be able to give informed consent.

Control arm - patients with stable heart failure:
1. There should be a prior diagnosis of CHF based on the presence of signs and symptoms of heart failure with objective evidence of a structural or functional abnormality of the heart at rest.
2. Patients should already be established on therapy, i.e. diuretics if required, ACE inhibitors/ARBs, beta blockers and aldosterone antagonists.
3. They should not have had a hospitalisation in the last 3 months.

Control arm - healthy age-matched particpants:
1. There should be no known cardiac abnormality or history of anaemia or iron deficiency.
2. They should not have any chronic conditions requiring aspirin, beta blockers, ACE inhibitors, ARBs or aldosterone antagonist therapy in the last 3 months.

Exclusion Criteria

1. Patients less than 18 years of age
2. Patients who are part of any other ongoing research study
3. Hospitalisation for stable heart failure or age-matched control patient in the last 3 months

Study & Design

• Study Type: Observational
• Study Design: Not specified