Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation
Phase 4
Completed
- Conditions
- Induction of Anaesthesia
- Interventions
- Registration Number
- NCT02186990
- Lead Sponsor
- T.C. ORDU ÜNİVERSİTESİ
- Brief Summary
The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this drugs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
- between 18 - 65 age
- ASA I - II status
- elective surgery
Exclusion Criteria
- emergency surgery
- pregnancy
- alcohol and drug abuse
- HT and cardiovascular disease
- BMI > 25 kg/m2
- hypersensitivity against study drug
- sedative drug use in last month
- difficult intubation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description propofol etomidate-propofol - etomidate etomidate - propofol-etomidate propofol -
- Primary Outcome Measures
Name Time Method haemodynamic values in ten minutes after intubation e.g., heart rate, blood pressure (mean arterial pressure)
- Secondary Outcome Measures
Name Time Method adverse effect of study drugs within in 30 minutes drug administration e.g. myoclonus, injection pain, allergy, skin rash
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which etomidate and propofol modulate hemodynamic responses during anesthesia induction?
How does the etomidate-propofol combination compare to standard-of-care agents in managing hemodynamic instability during intubation?
Which biomarkers could predict individual patient response to etomidate, propofol, or their combination in anesthesia?
What are the potential adverse events associated with etomidate and propofol use in anesthesia, and how can they be managed?
How do etomidate and propofol compare to other intravenous anesthetics like ketamine or thiopental in terms of hemodynamic effects and safety profiles?
Trial Locations
- Locations (1)
Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital
🇹🇷Altınordu, Ordu, Turkey
Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital🇹🇷Altınordu, Ordu, Turkey