Outcomes of intraoperative haemofiltration for patients with impaired kidney function undergoing coronary artery bypass graft surgery

Completed

Conditions: coronary heart disease
Preoperative renal impairment
Urological and Genital Diseases
cardiac artery bypass graft surgery

Registration Number: ISRCTN49513454

Lead Sponsor: iverpool Heart & Chest Hospital NHS Foundation Trust (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 60

Inclusion Criteria

1. Consenting men and women must be at least 18 years old
2. High-risk patients elective for on-pump coronary artery bypass graft surgery (CABG)
3. Impaired renal function established preoperatively by an estimated glomerular filtration rate (eGFR) <60 ml/min measured within 4 weeks before surgery

Exclusion Criteria

1. Patients undergoing surgery on the great vessels (aortic surgery)
2. Patients with significantly impaired liver function (serum bilirubin> 60 or INR>2 without anticoagulation)
3. Patients who are further down the line of renal failure or on-dialysis
4. Patients with malignancy
5. Those that are pregnant

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidents of ICU stay >3 days for patients with renal impairment identified as an estimated glomerular filtration (eGFR) <60 ml/min

Secondary Outcome Measures

Name	Time	Method
1. Clinical outcomes:<br>1.1. Composite of perioperative incidences: <br>1.1.1. Bleeding<br>1.1.2. Sepsis<br>1.1.3. Death<br>1.1.4. Arrhythmias<br>1.1.5. Stroke<br>1.1.6. Myocardial infarction <br>1.2. Need for postoperative continuous veno-venous haemofiltration (CVVH) in the ICU and wards - Indications for requirement of postoperative continuous veno-venous haemofiltration must adhere to our strict NHS Trust criteria and guidelines. <br>1.3. Mechanical ventilation time<br>1.4. Hospital stay<br>1.5. eGFR at 6 weeks follow-up<br>2. Economic outcomes: Resource utilisation and costs associated with each of the two pilot arms such as: <br>2.1. ICU stay and hospital stay<br>2.2. Mechanical ventilation<br>2.3. Medications<br>2.4. Tests and procedures undertaken until the end of the follow-up period