IRCT20171007036623N1
Recruiting
Phase 2
Investigation of gene expression and secretion of P53, LIF, IL_10, IL-17 after administration of tacrolimus in endometrial and uterine fluid in patients with repeated implantation failure: Clinical trial
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Recurrent Implantation Failure.
- Sponsor
- Shahid Beheshti University of Medical Sciences
- Enrollment
- 10
- Status
- Recruiting
- Last Updated
- 8 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •History of 3 or more failed IVF/ET cycles with morphologically and developmentally average to good\-quality embryo( 7 or more blastomeres and less than 10% fragmentation in day 3 ) into an adequately prepared endometrium (endometrial thickness equal or more than 8 mm); Women who had regular menses (25 to 35 days); Women who had normal karyotype;
- •women who had at least one of these Immunological disorders in their peripheral blood sample between day of 5 to 10 of menstrual cycle: IFN\-g/IL\-4 equal or more than 10\.3 or Nk\-cell percentage greater than 12%
Exclusion Criteria
- •Present of sub mucosal fibroids, endometrial polyps, intrauterine adhesions, congenital anomalies of uterus or hydrosalpinges
- •History of active autoimmune disease (With assessment of ANA, Anti\-TG, Anti\-TPO, Anti\-dsDNA); Women with acquired or inherited thrombophilia (With assessment of Factor2, Factor5, Factor 8, Fibrinogen, Anti\- Cardiolipin, Anti\-Phospholipid Antibody, Lupus Anti\-Coagulate, s\-MTHFR gene)
- •Pregnant women; History of miscarriage in a former IVF/ET cycle; Women who received vaccine in the last three months; Women who received steroid hormones in the last 2 months; Women receiving immunotherapy; Women with chronic inflammatory diseases
Outcomes
Primary Outcomes
Not specified
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