Immune paralysis in trauma patients: an explorative study

• Conditions: Immune paralysis; impaired function of the immune system following trauma; 10027665

• Registration Number: NL-OMON35513
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

Patients admitted to the UMC St Radboud with trauma

Exclusion Criteria

Age below 18,
expected clinical risks of blood sampling,
known HIV/AIDS,
conditions known to influence the immune response (e.g. auto-immune diseases),
use of medication known to influence the immune response (e.g. steroids)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Cytokine production following ex vivo whole blood stimulation to identify<br /><br>immune paralysis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Plasma mtDNA concentrations, mRNA expression levels of genes known to be<br /><br>involved in immune paralysis, other DAMP concentrations in plasma, infections,<br /><br>blood gas values, vital parameters, age, body mass index, trauma mechanism,<br /><br>Injury Severity Score (ISS), use of medication, surgical interventions.</p><br>