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临床试验/NCT07044102
NCT07044102已完成不适用

The Effect of Continuous Low Tidal Volume Ventilation During Cardiopulmonary Bypass on Renal Resistive Index

Konya City Hospital1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2025年7月15日最近更新:
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
60
试验地点
1
主要终点
Renal resistive ındex

研究概览

简要总结

Postoperative acute kidney injury following cardiopulmonary bypass surgery represents a significant barrier to patient recovery and is closely associated with increased postoperative morbidity and mortality. Studies have shown that the incidence of AKI aftercardiopulmonary bypass surgeryranges between 5% and 30%.

The Renal Resistive Index, measured by Doppler ultrasonography, is an increasingly utilized parameter that provides valuable insights into renal hemodynamics and vascular resistance. A normal RRI is typically below 0.70; elevated values may indicate increased renal vascular resistance or microvascular damage. Bossard et al. demonstrated that increased RRI in the early postoperative period is associated with the development of AKI. Early evaluation of renal blood flow thus facilitates prompt detection of AKI. Both preoperative and postoperative RRI measurements are considered useful tools for identifying early renal dysfunction. Monitoring RRI before and after CABG may provide critical information for preventing postoperative renal complications.

详细描述

Postoperative acute kidney injury following cardiopulmonary bypass surgery represents a significant barrier to patient recovery and is closely associated with increased postoperative morbidity and mortality. Studies have shown that the incidence of AKI after CABG ranges between 5% and 30%.

The Renal Resistive Index, measured by Doppler ultrasonography, is an increasingly utilized parameter that provides valuable insights into renal hemodynamics and vascular resistance. A normal RRI is typically below 0.70; elevated values may indicate increased renal vascular resistance or microvascular damage. Bossard et al. demonstrated that increased RRI in the early postoperative period is associated with the development of AKI. Early evaluation of renal blood flow thus facilitates prompt detection of AKI. Both preoperative and postoperative RRI measurements are considered useful tools for identifying early renal dysfunction. Monitoring RRI before and after CABG may provide critical information for preventing postoperative renal complications.In recent years, significant advancements have been made in both surgical and anesthetic techniques in cardiac surgery. During CABG, the commonly used ventilation strategy during cardiopulmonary bypass is apneic ventilation. However, low tidal volume ventilation has been proposed as an alternative, with a growing body of literature supporting its use. LTV has been associated with reduced postoperative pulmonary complications, earlier extubation, and prevention of atelectasis and pulmonary edema.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 85 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients scheduled for elective cardiac bypass surgery
  • Male and female patients over 18 years of age
  • Patients with an American Society of Anesthesiologists (ASA) physical status classification of II, III, or IV

排除标准

  • Chronic renal failure requiring dialysis
  • Patients requiring emergency surgery

研究组 & 干预措施

Patients Undergoing Low Tidal Volume Ventilation During CABG

Experimental

patients undergoing coronary artery bypass grafting receive continuous low tidal volume ventilation during cardiopulmonary bypass

干预措施: Patients Undergoing Low Tidal Volume Ventilation During CABG (Other)

Patients Managed With Apneic Ventilation During Cardiopulmonary Bypass"

Active Comparator

patients undergoing coronary artery bypass grafting are managed with apnea ventilation during cardiopulmonary bypass

干预措施: Patients Undergoing Apneic Ventilation During CABG (Other)

结局指标

主要结局

Renal resistive ındex

时间窗: Postoperative 45 minutes

Measurement of Changes in Renal Resistive Index Associated With Low Tidal Volume and Apneic Ventilation

次要结局

未报告次要终点

研究者

发起方
Konya City Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Esra GÖGER

Specialist Doctor, MD Anesthesiology and Reanimation

Konya City Hospital

研究点 (1)

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