The Effect of Continuous Low Tidal Volume Ventilation During Cardiopulmonary Bypass on Renal Resistive Index
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Renal resistive ındex
研究概览
简要总结
Postoperative acute kidney injury following cardiopulmonary bypass surgery represents a significant barrier to patient recovery and is closely associated with increased postoperative morbidity and mortality. Studies have shown that the incidence of AKI aftercardiopulmonary bypass surgeryranges between 5% and 30%.
The Renal Resistive Index, measured by Doppler ultrasonography, is an increasingly utilized parameter that provides valuable insights into renal hemodynamics and vascular resistance. A normal RRI is typically below 0.70; elevated values may indicate increased renal vascular resistance or microvascular damage. Bossard et al. demonstrated that increased RRI in the early postoperative period is associated with the development of AKI. Early evaluation of renal blood flow thus facilitates prompt detection of AKI. Both preoperative and postoperative RRI measurements are considered useful tools for identifying early renal dysfunction. Monitoring RRI before and after CABG may provide critical information for preventing postoperative renal complications.
详细描述
Postoperative acute kidney injury following cardiopulmonary bypass surgery represents a significant barrier to patient recovery and is closely associated with increased postoperative morbidity and mortality. Studies have shown that the incidence of AKI after CABG ranges between 5% and 30%.
The Renal Resistive Index, measured by Doppler ultrasonography, is an increasingly utilized parameter that provides valuable insights into renal hemodynamics and vascular resistance. A normal RRI is typically below 0.70; elevated values may indicate increased renal vascular resistance or microvascular damage. Bossard et al. demonstrated that increased RRI in the early postoperative period is associated with the development of AKI. Early evaluation of renal blood flow thus facilitates prompt detection of AKI. Both preoperative and postoperative RRI measurements are considered useful tools for identifying early renal dysfunction. Monitoring RRI before and after CABG may provide critical information for preventing postoperative renal complications.In recent years, significant advancements have been made in both surgical and anesthetic techniques in cardiac surgery. During CABG, the commonly used ventilation strategy during cardiopulmonary bypass is apneic ventilation. However, low tidal volume ventilation has been proposed as an alternative, with a growing body of literature supporting its use. LTV has been associated with reduced postoperative pulmonary complications, earlier extubation, and prevention of atelectasis and pulmonary edema.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for elective cardiac bypass surgery
- •Male and female patients over 18 years of age
- •Patients with an American Society of Anesthesiologists (ASA) physical status classification of II, III, or IV
排除标准
- •Chronic renal failure requiring dialysis
- •Patients requiring emergency surgery
研究组 & 干预措施
Patients Undergoing Low Tidal Volume Ventilation During CABG
patients undergoing coronary artery bypass grafting receive continuous low tidal volume ventilation during cardiopulmonary bypass
干预措施: Patients Undergoing Low Tidal Volume Ventilation During CABG (Other)
Patients Managed With Apneic Ventilation During Cardiopulmonary Bypass"
patients undergoing coronary artery bypass grafting are managed with apnea ventilation during cardiopulmonary bypass
干预措施: Patients Undergoing Apneic Ventilation During CABG (Other)
结局指标
主要结局
Renal resistive ındex
时间窗: Postoperative 45 minutes
Measurement of Changes in Renal Resistive Index Associated With Low Tidal Volume and Apneic Ventilation
次要结局
未报告次要终点
研究者
Esra GÖGER
Specialist Doctor, MD Anesthesiology and Reanimation
Konya City Hospital
