Muslce Oxygenation of the Quadricep Relative to Angle and Load
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 20
- 主要终点
- Muscle oxygenation (SmO2) curve during constant torque knee extension compared to joint angle
研究概览
简要总结
The purpose of the present study is to determine if the amount of oxygen in muscles during resistance exercise with different weights is related to changes in torque or knee joint angle. Participants will need to come to the lab three times over three weeks. On their first visit, we will test how strong their muscles are by testing the maximal weight that can be lifted in a single repetition of a knee extension referred to as a 1 repetition maximal (1RM) followed by exercise interventions during the second and third weeks. Each exercise session will have participants lift different amounts of weight. They will use two machines: the Biodex dynamometer, that maintains constant force during a knee extension and a standard weighted knee extension machine which has variable force outputs. Participants will perform these exercises against three levels of weight, making six tests in total. Their first exercise session will take about 70 minutes and the following sessions around 55-60 minutes. They will be provided a 5-minute break between each set of lifts to ensure they are fully rested. In total, participants will be exercising for about 25-30 minutes each visit, with the rest of the time spent resting. The weights will be different percentages of the heaviest weight participants can lift.
详细描述
Visit 1 (70 minutes) Informed Consent and Baseline Testing Session 1
After verbal consent for participation an in-person visit will be scheduled with the associate investigator which will take place in our research space at the Chan Gunn Pavilion.
You will be asked to bring comfortable exercise clothes to this visit.
The consent form will be reviewed with you to ensure you completely understand each aspect of your involvement in the trial. If you wish to participate, you will provide written consent by signing this document in person.
Upon registration into this trial, you will complete the CSEP-Get Active Questionnaire (CSEP-GAQ), in person, which will assess your ability to safely perform exercise, as well as a general activity questionnaire to assess your exercise habits over the past 12-months. The CSEP-GAQ you complete today will be the same as the version used during your initial phone call/email screening with the study coordinator (Jacob Sanders or Ashlesh Mathrani).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Able to understand and communicate in English
- •All "No" answers on the CSEP Get Active questionnaire
排除标准
- •Current use of cigarettes or other nicotine devices
- •Any major uncontrolled cardiovascular, muscular, metabolic, and/or neurological disorders
- •Any medical condition impacting the ability to participate in maximal exercise
- •Type one or type two diabetes
- •Diagnosis of cancer or undergoing cancer treatment in the past 12 months
- •Drug therapy with any drugs that alter skeletal muscle metabolism (i.e., Metformin, Benzodiazepines, hormone replacement therapy drugs)
结局指标
主要结局
Muscle oxygenation (SmO2) curve during constant torque knee extension compared to joint angle
时间窗: Within 55/60mins testing session during week 2 or 3.
Percent of SmO2 dynamic range (%SmO2 max) will be measured during constant torque knee extension conditions at 20, 40, and 60% 1RM at 18, 12, and 6 reps respectively. The SmO2 curve for each sextile of the reps range of motion will be compared to joint angle across the three loads.
Muscle oxygenation (SmO2) curve during variable torque knee extension compared to torque
时间窗: Within 55/60mins testing session during week 2 or 3.
Percent of SmO2 dynamic range (%SmO2 max) will be measured during variable torque knee extension conditions at 20, 40, and 60% 1RM at 18, 12, and 6 reps respectively. The SmO2 curve for each sextile of the reps range of motion will be compared to torque across the three loads.
次要结局
- Muscle oxygenation curve during variable torque compared to constant torque(Within 55/60mins testing session during week 2 or 3.)
研究者
Cameron Mitchell
Assistant Professor
University of British Columbia