AKIN Criteria: Acute Kidney Injury After On-Pump Coronary Artery Bypass Graft (CABG)

Completed

• Conditions: Kidney Failure

• Registration Number: NCT00780845
• Lead Sponsor: Hospital de Base

Brief Summary

The purpose of this study is evaluate clinical outcomes and 30-day mortality after on-pump CABG.

Detailed Description

Eight hundred and seventeen patients was enrolled in this series and divided into to groups: Group AKI (-) - patients without acute kidney injury after on-pump CABG. Group AKI (+) - patients with acute kidney injury after on-pump CABG. AKI was defined as an absolute increase in serum creatinine (SCr) of more than or equal to 0.3 mg/dl (≥ 26.4 μmol/l) or a percentage increase in SCr of more than or equal to 50% (1.5-fold from baseline). The change in SCr concentration was defined as the difference between immediate postoperative concentration and the highest concentration during the stay in ICU. Clinical Outcomes and 30-day mortality was evaluate in this patients.

Study Timeline

• Study Start: 2003-01
• Primary Completion: 2008-01
• Study Completion: 2008-01
• Status Verified: 2008-10
• Study First Submitted: 2008-10-27
• Study First Submitted QC: 2008-10-27
• Study First Posted: 2008-10-28
• Last Update Submitted: 2008-11-03
• Last Update Posted: 2008-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 817

Inclusion Criteria

• Patients underwent on-pump coronary artery bypass grafting
• Patients with at least two serum creatinine values within 48 hours.

Exclusion Criteria

• Patients with end-stage kidney disease requiring renal replacement therapy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To test the hypothesis that patients with acute kidney injury after on-pump CABG have higher 30-day mortality	30 days

Secondary Outcome Measures

Name	Time	Method
To compare clinical outcomes in patients with and without acute kidney injury after on-pump CABG	30 days