Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes Respiration
Not Applicable
Completed
- Conditions
- Heart Failure, CongestiveCheyne-Stokes Respiration
- Interventions
- Procedure: Experimental lung function test
- Registration Number
- NCT00495196
- Lead Sponsor
- ResMed
- Brief Summary
The purpose of the trial is to investigate the cardiovascular response to peripheral chemoreceptor stimulation in Congestive Heart Failure with Cheyne- Stokes Respiration
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 50
Inclusion Criteria
- Moderate to severe heart failure (NYHA Class II or above) on optimal medical therapy
- LVEF less than or equal to 45%
- Stable condition as defined as no hospital admission or changes to medical therapy within two weeks prior to enrolment
Exclusion Criteria
- Patients taking known respiratory stimulants or depressants
- Clinically significant asthma requiring therapy
- Significant parenchymal lung disease
- Primary pulmonary hypertension
- Myocardial infarction within three months prior to enrolment
- Patients with cardiac resynchronisation devices and permanent pacemakers
- Anaemic (haemoglobin < 12g/dL)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Experimental lung function test - 2 Experimental lung function test -
- Primary Outcome Measures
Name Time Method Cardiovascular parameters such as continuous blood pressure and heart rate. During administration of the intervention
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia