Effects of Lead Exposure on Iron Metabolism and the Nrf2-dependent Ferroptosis Pathway
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Concentration of TNF-α level in peripheral blood
研究概览
简要总结
The aim of this study was to investigate the effects of chronic lead exposure on iron metabolism and the Nrf2-dependent ferroptosis pathway in lead acid battery factory workers
详细描述
Background:
Lead (Pb) is a prevalent and highly toxic heavy metal. Human activities have been the primary cause of lead contamination in the environment over the past century. Lead exposure poses a global concern, particularly for children, and individuals can be exposed to lead through various means, such as contaminated soil, dust, food, water, or foreign objects. The central nervous system (CNS) is particularly vulnerable to the toxic effects of lead (Pb), especially in children, primarily due to the immaturity of the blood-brain barrier.
Ferroptosis is a recently defined form of regulated cell death characterized by iron-dependent cell death resulting from the accumulation of lipid hydroperoxides. However, the exact mechanism underlying the neurotoxic effects of chronic low-level lead exposure-induced ferroptosis on neuronal injury is not yet fully understood.
Methods:
The investigators first analyze the difference of blood lead level using atomic absorption spectrometry.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged over 18 years old
- •Work for the lead acid battery factory more than 10 years
排除标准
- •Neurological disorders
- •Endocrine diseases
- •Exposure to any chemical pollutant before
结局指标
主要结局
Concentration of TNF-α level in peripheral blood
时间窗: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 60 days
Biomarkers of the proinflammatory cytokines
The relative mRNA expression rate of the Nrf2- dependent ferroptosis genes in peripheral blood
时间窗: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 60 days
Biomarkers of the Nrf2- dependent ferroptosis
The relative mRNA expression rate of the iron metabolism genes in peripheral blood
时间窗: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 60 days
Biomarkers of the iron metabolism
次要结局
未报告次要终点
研究者
WenJing Zhao
Principal Investigator
Northern Jiangsu People's Hospital