NCT02893605已完成不适用
Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis
Centre Hospitalier Universitaire de Nīmes1 个研究点 分布在 1 个国家目标入组 800 人开始时间: 2014年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 800
- 试验地点
- 1
- 主要终点
- The polymorphisms occurring on a pre-defined set of genes
研究概览
简要总结
This is a case-control study performed on a biological collection. The polymorphisms present on a pre-defined list of genes will be studied for 400 Amyotrophic Lateral Sclerosis (sporadic type) DNA samples and 400 control DNA samples.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The primary inclusion criterium is the same for that of the parent biological collection, i.e. the patients fulfill requirements for probable or definite Amyotrophic Lateral Sclerosis as defined by revised international criteria (Brooks et al 2000).
- •Additionally, included patients were followed-up by doctors at the University Hospital of Montpellier, thus enabling verification of Amyotrophic Lateral Sclerosis criteria over time.
排除标准
- •The patient has a familial form of Amyotrophic Lateral Sclerosis (autosomic dominant or recessive types) with or without a mutation of one of the 3 genes known to be responsible for familial forms (SOD1, TARDBP, FUS). See Bender (1998).
结局指标
主要结局
The polymorphisms occurring on a pre-defined set of genes
时间窗: Day 0 (transversal study)
The genes studied are: CYP2R1, CYP27A1, CYP3A4, CYP2J2, CYP27B1, CYP24A1, VDBP, VDR.
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
Unknown
不适用
Effects of Gene Polymorphisms on Metabolic Features in Clozapine-treated Patients With SchizophreniaSchizophreniaSchizoaffective DisorderNCT01324167Taipei Medical University WanFang Hospital80
Unknown
不适用
Association of Multiple Genetic Polymorphisms With Clozapine-Associated Metabolic Change in SchizophreniaMetabolic SyndromeGenetic PolymorphismSchizophreniaNCT00717509Seoul National Hospital150
已完成
不适用
The Association Between Gene Polymorphisms and Infectious Complications After Liver SurgeryLiver DiseaseNCT00887887Maastricht University Medical Center100
已完成
不适用
Case-Control Viramune (Nevirapine) Toxicogenomics StudyHIV InfectionsNCT00310843Boehringer Ingelheim889
Unknown
不适用
Correlation of Genetic Polymorphisms and Clinical Parameters With the Complexity of Coronary Artery DiseaseCardiovascular Risk FactorCoronary ArteriosclerosisCoronary Artery DiseaseNCT03315234Aristotle University Of Thessaloniki270