Neurofeedback Improves Cognitive Performance and EEG Activity in Elderly With Mild Cognitive Impairment

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment
• Interventions: Behavioral: SMR neurofeedback training to MCI

• Registration Number: NCT03855319
• Lead Sponsor: Fabienne Marlats

Brief Summary

This is a non-pharmacological pilot study showing the improvement of a SMR/theta neurofeedback training program on cognitive performance and EEG activity in Elderly with Mild Cognitive Impairment.

Detailed Description

Neurofeedback training (NF) as self-regulation method of brain activity, may be beneficial in elderly with mild cognitive impairment. In this pilot study, the investigators studied whether a sensorimotor(SMR)/theta NF training could improve cognitive performance and brain electrical activity in a sample group of elderly patients with mild cognitive impairment. Twenty participants performed an electroencephalography recording, a battery of neuropsychological tests before the neurofeedback training program (T0), following the neurofeedback training program (T1) and 1-month follow-up (T2).

Study Timeline

• Study Start: 2016-12-15
• Primary Completion: 2018-12-15
• Study Completion: 2018-12-15
• Status Verified: 2019-02
• Study First Submitted: 2019-02-25
• Study First Submitted QC: 2019-02-25
• Study First Posted: 2019-02-26
• Last Update Submitted: 2019-02-26
• Last Update Posted: 2019-02-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Clinical diagnosis of Mild Cognitive Impairment
• education level of 9 years of studies minimum
• righthandedness
• subjective memory complaint confirmed by an informant
• a Mini Mental Status Examination score >20.
• preserve activity of daily living and absence of dementia.

Exclusion Criteria

• elderly persons who were under guardianship
• resident in nursing facilities
• neurological disease, psychiatric disease
• and involved in another cogniitve intervention.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
SMR neurofeedback training to MCI	SMR neurofeedback training to MCI	A sensorimotor/theta neurofeedback training consisted of 20 individuals sessions, twice a week during 11 weeks maximum. For each subject, NF was planned and conducted by a neuropsychologist experienced in neurophysiology an neurofeedback. Each session lasted 1h10 minutes and was conducted as follows: * Preparation and installation of the electrodes, verification of the impedance, adjustement of the calibration. * NF training (tasks and video described below)(45minutes) * Feedback and debriefing about the session (15 minutes)

Primary Outcome Measures

Name	Time	Method
Rey Auditory Verbal Learning test	Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up	Assessment of verbal learning in episodic memory, evaluating the ability to encode, combine, store and long-term consolidation process.

Secondary Outcome Measures

Name	Time	Method
Relative power for delta, theta, alpha, sensorimotor and lower beta frequency bands.	Assessment at baseline, change from baseline to 11 weeks immediately after the NF training and 1 month follow-up	Electroencephalography was recorded and EEG power spectrum was calculated using the fast Fourier transform. The power spectral density was calculated to extract the relative power for each frequency band and estimated as a log-ratio.