NEUROFEEDBACK TRAINING FOR OLDER ADULTS WITH MILD COGNITIVE IMPAIRMENT: A PILOT STUDY

Not Applicable

• Conditions: Mild Cognitive Impairment
• Interventions: Behavioral: Neurofeedback

• Registration Number: NCT04027725
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The purpose of this study is to evaluate the effects of SMR neurofeedback training on cognitive performance and electrical brain activity in elderly with cognitive impairment.

Detailed Description

Older adults with Mild Cognitive Impairment (MCI) are at high risk to progress to Alzheimer's disease (AD). Slowing down effect of dementia by enhancing brain plasticity represents on of the most prominent challenges. Neurofeedback is one of the promising techniques that showed therapeutic efficacy and cognitive improvement in attention-deficit hyperactivity disorder, epilepsy, stroke. The investigators aim to study the effects of a sensorimotor neurofeedback training protocol (SMR) on cognitive performances in elderly and to assess whether MCI patients change in brain electrical activity after training.

Study Timeline

• Study First Submitted: 2019-07-18
• Study First Submitted QC: 2019-07-19
• Study First Posted: 2019-07-22
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-18
• Last Update Posted: 2019-10-21
• Study Start: 2019-11
• Primary Completion: 2021-05
• Study Completion: 2021-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Clinical diagnosis of Mild Cognitive Impairment, educational level of 9 years of studies minimum, righthandedness, subjective memory complaint confirmed by an informant, a mini mental Status Examination score > 20, preserve activity of daily living and absence of dementia.

Exclusion Criteria

Elderly persons who were under guardianship, resident in nursing facilities, neurological disease, psychiatric disease and involved in another cognitive intervention.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sensorimotor neurofeedback training group	Neurofeedback	Three interventions will be administered : * An electroencephalography recording (EEG) for 30 minutes with an electrocap of 19 scalp locations according to the international 10-20 EEG placement system. * The second intervention is the neuropsychological assessments and questionnaires. They will be done in one session for approximately 2hours. * The third intervention is the neurofeedback training sensorimotor that will be recorded at channel Cz according to the international 10-20 system.

Primary Outcome Measures

Name	Time	Method
Change on Rey Auditory Verbal Learning test	Baseline assessment in 2 weeks period before intervention, change from baseline at immediately after the end of the intervention , and after 1-month follow-up	Assessment of Verbal learning in episodic memory

Secondary Outcome Measures

Name	Time	Method
relative power for delta, theta, alpha, sensorimotor and lower beta frequency bands.	assessment at baseline, change from baseline to immediately after the NF training and 1 month follow-up	Description : Electroencephalography was recorded and EEG power spectrum was calculated using the fast Fourier Transform. The power spectral density was calculated to extract the relative power for each frequency band and estimated as a log-ratio.

Trial Locations

Locations (1)

Hopital BROCA; 🇫🇷 Paris, France