Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes
试验速览
- 阶段
- 不适用
- 入组人数
- 150
- 主要终点
- assessment of fetal thymus size
研究概览
简要总结
The aim of this study is to assess the feasibility of visualizing the internal thoracic artery (ITA), establishing the normogram for ITA pulsatility index (PI), resistance index (RI) and acceleration/ejection time (AT/ET) at 24-32 weeks.
详细描述
Background: The internal thoracic artery arises from the subclavian artery as the first branch. It travels downward on the inside of the rib cage and then gives off six main branches; mediastinal, thymic, pericardiacophrenic, sternal, perforating and intercostal branches.
In literature, there are so many articles that have been focused on thymus size in pregnancies complicated with diabetes mellitus, fetal growth restriction, preterm rupture of membranes and so on. To the best of our knowledge, there is no paper about fetal ITA whose branch are feeding vessel of thymus and ITA Doppler velocity. The arteries supplying the thymus are branches of the internal thoracic, and inferior thyroid arteries. As far as it has been known, growing of a tissue depends on increased blood flow. Before detecting possible blood-flow changes in fetuses complicated with great obstetrics patologies, the investigators should obtain normal values of ITA Doppler velocity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 17 Years 至 45 Years(Child, Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •singleton pregnancy
- •having no fetal anomalies
- •healthy pregnant women age >17 and <45 years
- •between 24th-32nd gestational weeks
排除标准
- •fetuses with congenital aneuploidy or structural malformation
- •underlying chronic diseases
- •pregnant women complicated with gestational diabetes, Type 1-2 DM, hypertension (pregnancy-induced; chronic; preeclampsia), malignancy
- •pregnancy complicated with preterm premature rupture of membranes, preterm labour, fetal growth restriction and another obstetric complication
结局指标
主要结局
assessment of fetal thymus size
时间窗: Between 24th and 32nd gestational weeks
volume and perimeter and transvers diameter
Doppler indices for internal thoracic artery
时间窗: Between 24th and 32nd gestational weeks
Doppler indices (pulsatility index, resistance index, acceleration and ejection time)
次要结局
未报告次要终点
研究者
Betül Yakıştıran
specialist
Ankara City Hospital Bilkent
