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临床试验/NCT04686240
NCT04686240Unknown不适用

Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes

Ankara City Hospital Bilkent0 个研究点目标入组 150 人开始时间: 2021年1月最近更新:
适应症

试验速览

阶段
不适用
入组人数
150
主要终点
assessment of fetal thymus size

研究概览

简要总结

The aim of this study is to assess the feasibility of visualizing the internal thoracic artery (ITA), establishing the normogram for ITA pulsatility index (PI), resistance index (RI) and acceleration/ejection time (AT/ET) at 24-32 weeks.

详细描述

Background: The internal thoracic artery arises from the subclavian artery as the first branch. It travels downward on the inside of the rib cage and then gives off six main branches; mediastinal, thymic, pericardiacophrenic, sternal, perforating and intercostal branches.

In literature, there are so many articles that have been focused on thymus size in pregnancies complicated with diabetes mellitus, fetal growth restriction, preterm rupture of membranes and so on. To the best of our knowledge, there is no paper about fetal ITA whose branch are feeding vessel of thymus and ITA Doppler velocity. The arteries supplying the thymus are branches of the internal thoracic, and inferior thyroid arteries. As far as it has been known, growing of a tissue depends on increased blood flow. Before detecting possible blood-flow changes in fetuses complicated with great obstetrics patologies, the investigators should obtain normal values of ITA Doppler velocity.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
17 Years 至 45 Years(Child, Adult)
性别
Female
接受健康志愿者

入选标准

  • singleton pregnancy
  • having no fetal anomalies
  • healthy pregnant women age >17 and <45 years
  • between 24th-32nd gestational weeks

排除标准

  • fetuses with congenital aneuploidy or structural malformation
  • underlying chronic diseases
  • pregnant women complicated with gestational diabetes, Type 1-2 DM, hypertension (pregnancy-induced; chronic; preeclampsia), malignancy
  • pregnancy complicated with preterm premature rupture of membranes, preterm labour, fetal growth restriction and another obstetric complication

结局指标

主要结局

assessment of fetal thymus size

时间窗: Between 24th and 32nd gestational weeks

volume and perimeter and transvers diameter

Doppler indices for internal thoracic artery

时间窗: Between 24th and 32nd gestational weeks

Doppler indices (pulsatility index, resistance index, acceleration and ejection time)

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Betül Yakıştıran

specialist

Ankara City Hospital Bilkent

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