Pulse-Wave Velocity Measurement in Patients with Marfan Syndrome: Automated and Non-Invasive Assessment of the Regional Vascular Status for Risk Stratificatio

• Conditions: disturbed compliance of the vascular status; Marfan; 10007510; 10003216

• Registration Number: NL-OMON30274
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

Patients with Marfan syndrome with expected regionally impaired aortic wall compliance (eg. with an implanted aortic graft) will be recruited from the patient database at the AMC. Patients already undergoing an angiographic procedure, that are selected for additional pressure measurements and MRI, are recruited at the LUMC. Healthy volunteers will be age- and gender-matched to the Marfan patient population. Other inclusion criterion is the subject*s willingness to undergo (additional) MRI examinations at the LUMC.

Exclusion Criteria

Exclusion criteria are the standard MRI exclusion criteria (pacemakers, cerebral vascular clips, metallic splinters in the eye, pregnancy, claustrophobia).

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This non-invasive approach will demonstrate to be a clinically applicable,<br /><br>accurate and reproducible method with prognostic value for the vascular status<br /><br>of the aorta.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>