Long-term Function and Health Effects of Intentional Weight Loss in Obese Elders
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Weight Loss
- Sponsor
- Wake Forest University Health Sciences
- Enrollment
- 588
- Locations
- 1
- Primary Endpoint
- 400 meter walk time
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Aging is associated with significant declines in muscle mass, strength, and physical performance, all of which lead to disability, loss of independence, and adverse clinical outcomes. Obesity exacerbates these age-related declines in function and is associated with poorer clinical outcomes and quality of life. Weight loss can also worsen age-related loss of muscle mass and decrease bone mineral density. The overall goals of this study are to determine if the short-term functional benefits of intentional weight loss are sustained long-term, and to examine the long-term benefits and risks of weight loss.
Detailed Description
Obesity exacerbates age-related declines in function and is associated with poorer clinical outcomes and quality of life. Although clinical trials conducted study teams show that diet-induced weight loss interventions in obese older adults, when combined with exercise, improve body composition and physical and metabolic function in the short-term, the overall safety and long-term benefits of intentional weight loss in older adults remain controversial. Weight loss can also worsen age-related loss of muscle mass and decrease bone mineral density. Because of these concerns, health care providers are reluctant to recommend weight loss in obese older adults. The goal is to determine whether weight loss-induced improvements in body composition and physical and metabolic function observed in short-term clinical trials persist over time is critical to inform geriatric obesity treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All former participants from the five intervention trials who respond to our recruitment strategies will be scheduled for clinic/home visits or a phone interview.
Exclusion Criteria
- •None - all former participants from the five intervention trials are eligible
Outcomes
Primary Outcomes
400 meter walk time
Time Frame: Baseline
Participants are instructed to complete the 400 m distance (on a flat indoor surface) as quickly as possible at a maintainable pace and the time to complete the walk is recorded in seconds.
Secondary Outcomes
- Knee extension strength(Baseline)
- Total body fat mass(Baseline)
- Subcutaneous abdominal fat(Baseline)
- Appendicular lean mass(Baseline)
- Interleukin-6(Baseline)
- Glucose(Baseline)
- Insulin(Baseline)
- LDL cholesterol(Baseline)
- Short Physical Performance Battery score(Baseline)
- Total body lean mass(Baseline)
- Femoral neck BMD(Baseline)
- Lumbar spine BMD(Baseline)
- Visceral abdominal fat(Baseline)
- Diastolic blood pressure(Baseline)
- Soluble tumor necrosis factor receptor 1(Baseline)
- Total hip BMD(Baseline)
- Thigh inter-muscular adipose tissue(Baseline)
- Total cholesterol(Baseline)
- Systolic blood pressure(Baseline)
- HDL cholesterol(Baseline)
- Triglycerides(Baseline)
- C-reactive protein(Baseline)