Youth Experience Study (JES): Traumatic life events in childhood and its relation to child psychopathology

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 650

Inclusion Criteria

Children under treatment:
i) need to be between 12 and 17 years old;Siblings:
i) need to be at least 12 years of age (no upper age limit); ii) at least one sibling needs to participate (if available) and iii) more than one sibling is allowed to participate (if available).;Parents of controls:
i) need to be the biological parent; ii) participation is preferred, however not needed for cases and their siblings to be included into the study and iii) more than one parent is allowed to participate.;Controls:
i) need to be between 12 and 17 years old.;Parents of controls:
i) need to be the biological parent; ii) participation is preferred, however not needed for controls to be included into the study and iii) more than one parent is allowed to participate.

Exclusion Criteria

For all participants:
When a participant (child and/ or parent) does not want to be informed about any possible clinically relevant findings that can be found throughout the study. ;Cases:
i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language; iii) being diagnosed with an Autistic Spectrum Disorder according to the DSM-IV with the exception of Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and iv) being adopted. ;Siblings:
i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language; iii) being diagnosed with an Autistic Spectrum Disorder according to the DSM-IV with the exception of PDD-NOS and iv) being adopted.;Parents of cases:
i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language.;Controls:
i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language; iii) being diagnosed with an Autistic Spectrum Disorder according to the DSM-IV with the exception of PDD-NOS; iv) being adopted and v) in the presence of a lifetime history of treatment at a mental health care institution. ;Parents of controls:
i) Mental Retardation (IQ score below 70); ii) insufficient knowlege of the Dutch language.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main parameter is current psychopathology (defined as (1) psychotic<br /><br>symptoms, (2) depressive symptoms, and (3) symptoms of anxiety) as well as the<br /><br>development of psychopathology within a timeframe of 2 years, depending on<br /><br>exposure to traumatic experiences.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To identify the mechanisms by which trauma leads to psychopathology<br /><br>a. stress sensitivity<br /><br>b. family situation (e.g. attachment)<br /><br>c. molecular genetic variation<br /><br>d. social cognition </p><br>