terine fluid lactate dehydrogenase isoenzyme activity profile. Can it be considered a diagnostic marker for endometrial cancer?
Not Applicable
- Conditions
- endometrial cancerCancer - Womb (Uterine or endometrial cancer)
- Registration Number
- ACTRN12614000135617
- Lead Sponsor
- alexandria univerisity
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
females with postmenopausal uterine bleeding
even one episode of bleeding will be included in the study
Exclusion Criteria
Patients with recent endometrial sampling.
Current hormone replacement therapy
Uterine fluid collection at TVS
Clinical signs of endometritis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method diagnostic accuracy of LD isoenzyme activity in post menopausal uterine bleeding for early detection of endometrial cancer compared to histopathological examination of endometrial tissues.[ after histopathological examination of endometrial tissues have been completed.]
- Secondary Outcome Measures
Name Time Method assessment of accuracy of LD isoenzyme activity in endometrial thickness less than and above 5 mm through comparison with histopathological examination of endometrial tissues.[ Immediately after histopathological examination of endometrial tissues have been completed.]
Related Research Topics
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What molecular mechanisms link uterine fluid LDH isoenzyme activity to endometrial cancer progression?
How does LDH isoenzyme profiling compare to CA-125 and HE4 in endometrial cancer diagnosis accuracy?
Which endometrial cancer subtypes (e.g., endometrioid, serous) show distinct LDH isoenzyme activity patterns?
Are there specific metabolic pathways or biomarkers synergistically affected by LDH isoenzyme alterations in uterine fluid?
What are the potential adverse events associated with uterine fluid collection for LDH isoenzyme analysis in clinical practice?