A Pilot Study of 566C80 for the Salvage Treatment of Toxoplasmic Encephalitis in Patients Infected With the Human Immunodeficiency Virus (HIV) Who Have Failed or Are Intolerant of Pyrimethamine-Sulfadiazine
- Conditions
- Toxoplasmosis, CerebralHIV Infections
- Registration Number
- NCT00001994
- Lead Sponsor
- Glaxo Wellcome
- Brief Summary
To evaluate the safety and tolerance of atovaquone (566C80) in AIDS patients with central nervous system (CNS) toxoplasmosis. To evaluate the efficacy of 566C80 in the acute treatment and suppression of CNS toxoplasmosis in AIDS patients who fail or who cannot tolerate conventional therapy.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (22)
Los Angeles County - USC Med Ctr
🇺🇸Los Angeles, California, United States
Johns Hopkins Hosp
🇺🇸Baltimore, Maryland, United States
Gathe, Joseph, M.D.
🇺🇸Houston, Texas, United States
Duke Univ Med Ctr
🇺🇸Durham, North Carolina, United States
SUNY / Health Sciences Ctr at Stony Brook
🇺🇸Stony Brook, New York, United States
Portland Veterans Adm Med Ctr / Rsch & Education Grp
🇺🇸Portland, Oregon, United States
Beth Israel Med Ctr
🇺🇸New York, New York, United States
Infectious Disease Physicians Inc
🇺🇸Annandale, Virginia, United States
Georgetown Univ Med Ctr
🇺🇸Washington, District of Columbia, United States
Infectious Disease Research Consortium of Georgia
🇺🇸Atlanta, Georgia, United States
Davies Med Ctr
🇺🇸San Francisco, California, United States
Saint Vincent's Hosp and Med Ctr
🇺🇸New York, New York, United States
Harlem Hosp Ctr
🇺🇸New York, New York, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Wellesley Hosp
🇨🇦Toronto, Ontario, Canada
Infectious Disease Med Group
🇺🇸Oakland, California, United States
San Francisco Gen Hosp
🇺🇸San Francisco, California, United States
UCSF - San Francisco Gen Hosp
🇺🇸San Francisco, California, United States
Dr Emil Toma / Hotel Dieu de Montreal
🇨🇦Montreal, Quebec, Canada
Regional Med Ctr at Memphis
🇺🇸Memphis, Tennessee, United States
Dr Julio S G Montaner
🇨🇦Vancouver, British Columbia, Canada
Southern Alberta HIV Clinic / Foothills Hosp
🇨🇦Calgary, Alberta, Canada