Assessment of Fluid Responsiveness in Septic Shock Patients, Can End-tidal co2 Measurement Help?, a Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- end tidal co2
研究概览
简要总结
Fluid therapy is important in patients with sepsis and septic shock. There are many invasive and non-invasive methods to assess fluid responsiveness in patients. The specificities and sensitivities of these methods are highly variable. The reason for our study was to determine end-tidal co2 and fluid responsiveness in septic shock patients. The aim of the study was to evaluate the fluid response using the End-tidal CO2 difference in septic shock patients receiving intubated mechanical ventilation support.
详细描述
End-tidal CO2 is a parameter that can be easily measured with our non-invasively available monitors. If results are positive, fluid response of patients can be measured with a non-invasive, easy-to-apply method.
The significance of end-tidal CO2 will be confirmed by the passive leg raise test. Assessment of fluid responsiveness with the passive leg raise test is currently seen as the non-invasive reference test used.
It has proven its accuracy and reliability in many studies. In the passive leg raise test, end-tidal CO2 will be compared between the group with and without fluid responsiveness.
Scope of the study: Patients hospitalized in the general and reanimation intensive care units of our hospital and diagnosed with septic shock for any reason.
Method(s) to be applied: All patients diagnosed with septic shock will be included in the study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •over 18 years old
- •in circulatory shock
- •Hemodynamically stable for 10 minutes (whether or not he takes vasoactive drugs)
- •Followed in mechanical ventilation with invasive arterial monitoring
排除标准
- •Heart cannot be visualized by echocardiography
- •Patients for whom passive leg raise test cannot be performed
- •Bilateral lower extremity amputation
- •Patients who are hemodynamically unstable
结局指标
主要结局
end tidal co2
时间窗: Recording will be made 3rd minute after the end of the test.
the level of carbon dioxide that is released at the end of an exhaled breath
次要结局
- ppv values(Recording will be made 3rd minute after the end of the test.)
- diastolic blood pressure(Recording will be made 3rd minute after the end of the test.)
- systolic blood pressure(Recording will be made 3rd minute after the end of the test.)
- vci distensibility(Recording will be made 3rd minute after the end of the test.)
研究者
hüseyin özkarakaş
intensive care specialist Medical Doctor
Bozyaka Training and Research Hospital