The Effect of Rapid Fluid Challenge Under Pulmonary Artery Catheter Monitoring on Physiological Indexes of Patients With Septic Shock
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Septic Shock
- Sponsor
- Chengdu Fifth People's Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- cardiac index change
- Last Updated
- 5 years ago
Overview
Brief Summary
Fluid challenge is often carried out in septic shock patients. Its responsiveness usually requires invasive monitoring. The pulmonary artery catheter(PAC) is the most effective means of monitoring.To use non-invasive methods is very tempting. Investigators hypothesize that venous-to-arterial carbon dioxide difference,venous-to-arterial carbon oxygen difference, central venous-arterial carbon dioxide to arterial-venous oxygen content ratio and Central Venous SO2 variations provides feasible estimation on fluid responsiveness in septic shock patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •more than 18 years old; less than 75 years old ICU patients
- •Septic shock
- •Monitored with pulmonary artery catheter (Swan-Ganz catheter)
- •The decision of fluid challenge made by the treating physician
Exclusion Criteria
- •Evidence of fluid overload
- •Pregnancy
- •Recently participated in other studies
- •Severe heart failure
Outcomes
Primary Outcomes
cardiac index change
Time Frame: Immediately after fluid challenge
Fluid responsiveness: increase in CI of at least 10% after fluid challenge ;Fluid nonresponsiveness:no increase or increase in CI less than 10%.