Determinants of Balance Recovery After Stroke - Retrospective Study

Completed

• Conditions: Stroke

• Registration Number: NCT03203109
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Postural and gait disorders in relation to referential of verticality have been analyzed in routine care.

Detailed Description

300 consecutive patients, admitted in our department for neurorehabilitation after a first hemispherical stroke, have been enrolled retrospectively. During their hospitalisation, all patients have been routinely evaluated with clinical scales, evaluating motor and cognitive deficits. Postural and visual vertical (VV) assessments have been performed 1 to 4 times during in-patient-stay.

The objective was to analyse the determinants of balance recovery after stroke, in particular the impact of wrong referential of verticality.

Data collection was performed by means of medical records. Observation period covered from january 2012 to february 2018.

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2017-05-02
• Study First Submitted QC: 2017-06-28
• Study First Posted: 2017-06-29
• Primary Completion: 2019-10-31
• Study Completion: 2019-10-31
• Status Verified: 2019-11
• Last Update Submitted: 2019-11-07
• Last Update Posted: 2019-11-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

first hemispheric stroke patient non-opposed to inclusion

Exclusion Criteria

history of neurological disorders interfering with balance history of vestibularly disorders interfering with balance unstable medical conditions history of cognitive disorders

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Posture	admission and monthly, up to 3 months	Change from Baseline Score of Postural Assessment Scale for Stroke (PASS) at discharge

Secondary Outcome Measures

Name	Time	Method
Postural vertical perception	admission and monthly, up to 3 months	Assessment of the postural vertical (pv). Subject is seated in a specific device (CE-marked) in darkness, and indicates which direction of her/his whole body is perceived as vertical in the roll plane.
Neuropsychological Assessment 1	admission and monthly, up to 3 months	Assessment of Hemispatial Neglect with the Catherine Bergego Scale (CBS)
Neuropsychological Assessment 2	admission and monthly, up to 3 months	Assessment of Hemispatial Neglect with the fluff Test
Neuropsychological Assessment 5	admission and monthly, up to 3 months	Assessment of Hemispatial Neglect with the BEN ( Battery of tests for the quantitative assessment of unilateral neglect)
Balance	admission and monthly, up to 3 months	Assessment of Balance and Posture with SCP (Scale for Contraversive Pushing)
Walking distance	admission and monthly, up to 3 months	Assessment of walking distance with the 6-minute-walking-test (6-MWT)
Gait velocity	admission and monthly, up to 3 months	Assessment of gait velocity at self-prefered-velocity on 10 meters
Laterality	admission and monthly, up to 3 months	Assessment of Laterality with Edinburgh Handedness Inventory
Neuropsychological Assessment 4	admission and monthly, up to 3 months	Assessment of Hemispatial Neglect with the 'Comb and Razor Test'
Neuropsychological Assessment 7	admission and monthly, up to 3 months	Assessment of Language with LAST (Language Screening Test)
Neuropsychological Assessment 6	admission and monthly, up to 3 months	Assessment of Apraxia with ATS (Apraxia Screen of TULIA)
Postural disorders	admission and monthly, up to 3 months	Assessment of Postural control with CDP (Computerized posturography)
Spasticity	admission and monthly, up to 3 months	Assessment of Spasticity with Ashworth Scale
Neuropsychological Assessment 3	admission and monthly, up to 3 months	Assessment of Hemispatial Neglect using 'thumb localizing test' (TLT)
Gait	admission and monthly, up to 3 months	Assessment of Gait with Lindmark test
Pressure sensitivity (Hand and foot)	admission and monthly, up to 3 months	Assessment of hypoesthesia with Semmes-Weinstein monofilaments test
Neuropsychological Assessment 8	admission and monthly, up to 3 months	Assessment of Aphasia with BDAE (Boston Diagnostic Aphasia Examination)
Falls	at discharge, the number of falls is totalized	Monitoring of falls occuring during the hospitalization
Visual field defect (hemianopia/quadranopia)	admission and monthly, up to 3 months	standardized clinical examination
Visual vertical perception	admission and monthly, up to 3 months	Assessment of the visual vertical (vv). Subject indicates which direction a visual line displayed on a computer screen (in darkness) is perceived as vertical in the roll plane.
Disability	admission and monthly, up to 3 months	Assessment of Autonomy with FIM (Functional Independence Measure)
Neuropsychological Assessment 10	admission and monthly, up to 3 months	Assessment of depression with ADRS (Aphasia Depression Rating Scale)
Identification of brain structures involved in the stroke	once, at 2 month	anatomical MRI