Anti-inflammatory effect of Simvastatin and its impact on Western Ontario and McMaster Universities (WOMAC) scores in patients with mild to moderate knee osteoarthritis.

Indian Council of Medical Research New Delhi0 个研究点目标入组 180 人开始时间: 待定最近更新: 2021年11月24日

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•Patients with American society of anesthesiologist (ASA) Iâ??II ,mild to moderate knee OA based on clinical history of knee pain with grade 1-3 of Kellgren-Lawrence radiological grading for OA and having at least one of the following:
•Patient age 50-80 years
•Morning stiffness lasting 30 minutes or less
•Crepitus on motion
•Patients receiving standard non pharmacological and medical treatment of OA since three months without any significant alterations.

•Patient refusal
•A body mass index (BMI) >40 kg/m2.
•Patients who are receiving drugs that might interact with statins. Ciclosporins , Fibrates, Azol anti-fungals, Macrolide antibiotics, Antiarrhthymics(Verapamil, Amiodarone), Nefazodone ,Arotease inhibitors, anticoagulants ,tramadol and paracetamol combinations.
•OA due to trauma, referred pain syndromes, septic/crystal arthritis and hemarthrosis and soft tissue conditions.
•Patients with diabetes, serious medical condition, renal and hepatic disease, or deranged function tests.
•Patients with existing pregnancy or breastfeeding.
•Patients with Known hypersensitivity to Simvastatin

发起方

Indian Council of Medical Research New Delhi