Reported Time Between Onset and Diagnosis of Alzheimer's Disease: Correlation With Objective Parameters

Completed

• Conditions: Alzheimer Disease
• Interventions: Other: Medical file data extraction

• Registration Number: NCT03408041
• Lead Sponsor: Murielle Surquin

Brief Summary

The early diagnosis of Alzheimer's disease is essential to enable patients to have access to the available treatments. However, there is a delay between the diagnosis and the onset of symptoms, which can range from 1 year to more than 5 years. In clinical practice, the hippocampal volume, measured by the Scheltens index, is currently used as a marker of the progression of the disease.

The purpose of this study is to determine whether the patient's sex, age and ethnicity can influence the delay in the expression of cognitive troubles reported by the family at the first medical consultation, as well as to determine if there is a correlation between the delay reported by the family and the Scheltens index.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-05-01
• Primary Completion: 2017-10-01
• Study Completion: 2017-10-01
• Status Verified: 2018-01
• Study First Submitted: 2018-01-17
• Study First Submitted QC: 2018-01-17
• Last Update Submitted: 2018-01-17
• Study First Posted: 2018-01-23
• Last Update Posted: 2018-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 129

Inclusion Criteria

Alzheimer Disease patients admitted in the 'Memory Clinic' of the CHU Brugmann Hospital between 01-01-2010 and 31-01-2013. Diagnose according to the Dubois criteria

Exclusion Criteria

None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Alzheimer Disease	Medical file data extraction	Alzheimer Disease patients admitted in the 'Memory Clinic' of the CHU Brugmann Hospital between 01-01-2010 and 31-01-2013. Diagnose according to the Dubois criteria

Primary Outcome Measures

Name	Time	Method
Age	Between 01-01-2010 and 31-01-2013	Age
Sex	Between 01-01-2010 and 31-01-2013	Sex
Ethnic origin	Between 01-01-2010 and 31-01-2013	Ethnic origin
Symptoms-diagnose time interval	Between 01-01-2010 and 31-01-2013	Interval of time between the apparition of the first symptoms, as reported by the family, and the diagnose.
Scheltens scale	Between 01-01-2010 and 31-01-2013	Evaluation of the hippocampal atrophy by means of magnetic resonance imaging. Scale from 0 (normal) to 4.

Trial Locations

Locations (1)

CHU Brugmann; 🇧🇪 Brussels, Belgium