Thrombocyte function and the relationship to blood loss and need for transfusion during coronary artery bypass surgery.
Completed
- Conditions
- Thrombocyte dysfunction during cardiac surgery1001108210007593
- Registration Number
- NL-OMON34435
- Lead Sponsor
- Catharina-ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Elective CABG-procedure with use of extracorporale circulation
Group 1: Minimum of 5 days use of clopidogrel and aspirin until day of procedure.
Group 2: Minimum of 5 days use of aspirin until the day of procedure, but no clopidogrel use for at least 5 days prior to the procedure.
Exclusion Criteria
Use of coumarines or (low molecular weight) heparin
Clinical or laboratory signs of hemorrhagic diathesis
Cardiac failure
Renal insufficiency or dialysis
Liver failure
Chronic alcoholism
Age <18 years
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Outcome if the different labortory tests of platelet function<br /><br>Blood loos during and within 24 hours after the surgical procedrue<br /><br>Transfused number of units during and within 24 hours after the surgical<br /><br>procedure</p><br>
- Secondary Outcome Measures
Name Time Method <p>Correlation between the different thrombocyte function tests in the two studied<br /><br>populations</p><br>