Assessment of Bioavailability of Phenolics From an Orange Peel Extract
Not Applicable
Completed
- Conditions
- Improving Bioavailability
- Interventions
- Dietary Supplement: phenolics form orange peel
- Registration Number
- NCT02033330
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
In this study, the bioavailability of a specific orange peel extract is tested. The composition and morphology of the test product is altered compared to the generic product, which is used as a control. Due to intellectual property issues, more information cannot be given at this moment. Also the difference in bioavailability between a capsule and a lozenge is tested. The hypothesis is that the bioavailability of the altered extract will be improved compared to the control.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
Inclusion Criteria
- healthy adults
- BMI 18.5 to 25
Exclusion Criteria
- pregnancy
- smoking
- alcohol or drug abuse
- use of medication
- use of nutritional supplements
- abnormal liver or kidney function
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description phenolics form orange peel, type 1 phenolics form orange peel 1 dose of 500 mg of phenolics from orange peel, orally ingested phenolics from orange peel, type 2 phenolics form orange peel 1 dose of 500 mg of phenolics from orange peel, orally ingested phenolics from orange peel, type 3 phenolics form orange peel 1 dose of 500 mg of phenolics from orange peel, orally ingested
- Primary Outcome Measures
Name Time Method plasma concentrations of specific phenolics and their metabolites up to 24 hours
- Secondary Outcome Measures
Name Time Method urine concentrations of specific phenolics and their metabolites 24 hours
Trial Locations
- Locations (1)
Maastricht University Medical Centre
🇳🇱Maastricht, Netherlands