Bioavailability of Anthocyanins and Phenolic Acids and Changes in Blood Antioxidant Capacity After Consumption of Purple Wheat Anthocyanin-enriched Crackers and Granola Bars by Healthy Adult Participants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Plasma concentrations of anthocyanin metabolites
研究概览
简要总结
This study will determine the bioavailability of anthocyanins and phenolic compounds from two purple wheat products, i.e. bran-enriched wholegrain purple wheat crackers and bran-enriched wholegrain purple wheat granola bars. Crackers are an example of a baked/ processed product. The purple wheat granola bars are an example of a food product that requires much less intensive preparation and cooking, compared to the crackers. A comparison of bioavailability between these two products should provide insights about how different processes and food matrix influence anthocyanin bioavailability and metabolism.
详细描述
This study will determine the bioavailability of anthocyanins and phenolic compounds from two purple wheat products, i.e. bran-enriched wholegrain purple wheat crackers and bran-enriched wholegrain purple wheat granola bars. Crackers are an example of a baked/ processed product. The purple wheat granola bars are an example of a food product that requires much less intensive preparation and cooking, compared to the crackers. A comparison of bioavailability between these two products should provide insights about how different processes and food matrix influence anthocyanin bioavailability and metabolism. The study is a crossover investigation with 8 men and 8 women who will adhere to a low anthocyanin and low phenolic diet for the duration and complete 2 postprandial study visits where, in random order, they will consume either the crackers or granola bars. Blood and urine will be collected at baseline and postprandially for the analysis of anthocyanins and their metabolites and phenolic acids and determination of antioxidant capacity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI of 18 - 27 kg/m2
- •Generally healthy as determined by screening questionnaire
- •Non-smoking
- •Non to moderate alcohol drinkers (Typical consumption less than 5 drinks per sitting and no more than 14 per week)
排除标准
- •Pregnant or breast-feeding females
- •History of any major disease or medical condition, including any disorder of the gastrointestinal system or food intolerances
- •Taking any prescription medications (including hormonal contraceptives) or over the counter medications prescribed by a medical professional
- •Taking any natural health products or dietary supplements, other than a multivitamin low in anthocyanins and phenolic acids
- •Oral antibiotic use in the past 3 months
- •Any food allergies, and any anaphylactic or life-threatening allergies - food or otherwise
- •Smokers or use of recreational drugs (marijuana, magic mushrooms, etc)
- •Elite or training athletes
- •Following a vegan or vegetarian diet
研究组 & 干预措施
Purple Wheat Crackers
Bran-enriched purple wheat wholegrain crackers served in 120 g portion.
干预措施: Purple Wheat Crackers (Other)
Purple Wheat Granola Bars
Bran-enriched purple wheat wholegrain granola bars served in 160 g portion.
干预措施: Purple Wheat Granola Bars (Other)
结局指标
主要结局
Plasma concentrations of anthocyanin metabolites
时间窗: 0-8 hours (0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8)
次要结局
- Urinary concentrations of phenolic acids(0-8 hours (0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8))
- Plasma concentrations of phenolic acids(0-8 hours (0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8))
- Plasma antioxidant capacity(0-8 hours (0, 2, 4, 6, 8))
- Urinary concentrations of anthocyanin metabolites(0-8 hours (0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8))
研究者
Amanda Wright, Ph.D.
Associate Professor
University of Guelph