Assessment of Bioavailability of Phenolics From an Orange Peel Extract
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- plasma concentrations of specific phenolics and their metabolites
研究概览
简要总结
In this study, the bioavailability of a specific orange peel extract is tested. The composition and morphology of the test product is altered compared to the generic product, which is used as a control. Due to intellectual property issues, more information cannot be given at this moment. Also the difference in bioavailability between a capsule and a lozenge is tested. The hypothesis is that the bioavailability of the altered extract will be improved compared to the control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy adults
- •BMI 18.5 to 25
排除标准
- •pregnancy
- •alcohol or drug abuse
- •use of medication
- •use of nutritional supplements
- •abnormal liver or kidney function
研究组 & 干预措施
phenolics form orange peel, type 1
1 dose of 500 mg of phenolics from orange peel, orally ingested
干预措施: phenolics form orange peel (Dietary Supplement)
phenolics from orange peel, type 2
1 dose of 500 mg of phenolics from orange peel, orally ingested
干预措施: phenolics form orange peel (Dietary Supplement)
phenolics from orange peel, type 3
1 dose of 500 mg of phenolics from orange peel, orally ingested
干预措施: phenolics form orange peel (Dietary Supplement)
结局指标
主要结局
plasma concentrations of specific phenolics and their metabolites
时间窗: up to 24 hours
次要结局
- urine concentrations of specific phenolics and their metabolites(24 hours)