The direct effects of non-steroidal anti-inflammatory drugs (NSAIDS) on osteoarthritic knee cartilage

Completed

• Conditions: Osteoarthritis; Musculoskeletal Diseases; Polyarthrosis

• Registration Number: ISRCTN90366351
• Lead Sponsor: niversity Medical Centre Utrecht (UMCU) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12-20
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 42

Inclusion Criteria

Patients with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria, considered for total knee replacement surgery.

Exclusion Criteria

1. Total knee replacement for other reason than osteoarthritis
2. History of gastro-intestinal bleedings or perforation
3. Increased risk for cardiovascular diseases (cardiovascular diseases in history, patients with untreated hypertension, patients with angina pectoris, and patients on oral anticoagulants)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in proteoglycan release of osteoarthritic cartilage after treatment

Secondary Outcome Measures

Name	Time	Method
Prosteoglandin E2 levels produced by cartilage