Effect of selective COX-2 inhibition on neuroinflammation in Parkinson's disease.
Phase 2
Completed
- Conditions
- Paralysis agitans. Parkinson.10028037
- Registration Number
- NL-OMON31350
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
Age over 40 yr
No cognitive disturbances
Probable PD according to criteria by Gelb
Early stage Hoehn and Yahr 1-2
Exclusion Criteria
Cardiovascular brain diseases
Usage of antiinflammatory drugs
Gastrointestinal ulcers or bleeding
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Analysis methods<br /><br>[11C]-PK111-95 Binding Potential (BP) images will be generated based on a<br /><br>simplified reference tissue model4;13. Cluster analysis will be used to extract<br /><br>and identify a normal brain reference input function for individual PD cases.<br /><br>The reference tissue model will be compared to parametric analysis, using<br /><br>plasma input data and Logan analysis to generate distribution volume images.<br /><br>Pixel-by-pixel analysis will be done using Statistical Parametric Mapping<br /><br>program (SPM2)14. A coupled t-test will be applied to evaluate differences<br /><br>between the two scans. P-value of 0.001, uncorrected for multiple comparisons /<br /><br>0.05 after correction will be taken for statistical significance.</p><br>
- Secondary Outcome Measures
Name Time Method <p>nvt</p><br>