Study to compare different drugs with different routes in nasal surgery to compare blood loss, visiblity and better outcome.

Not yet recruiting

• Conditions: Acute sinusitis, unspecified,

• Registration Number: CTRI/2020/05/025037

Brief Summary

a placebo controlled study to compare the hypotensive effect of intravenous dexmedetomidine infusion versus premedication with oral metoprolol under sevoflurane anaesthesia for functional endoscopic sinus surgery in terms of mean arterial pressure and surgical field visibility. study will be done on 90 patients psted for FESS with 30 patients in each 3 groups. group A will be given intravenous infusion of dexmedetomidine intraoperatively loading dose of 1mcg/kg followed by continuous infusion of 0.2-0.5mcg/kg/hr. group B will be given oral metoprolol as a premedicant 50 mg night before surgery and 50 mg 2 hours prior to surgery. group C will be given placebo. anaesthesia will be given by inhalational sevoflurane in all 3 groups and supplementing with propofol as needing for lowering blood pressure.

intraopeartive hemodynamic parameters, blood loss, field visibility will be checked. post operative surgeons satisfaction score will be noted with complications occuring perioperatively.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-02-05
• Study Start: 2020-10-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

ASA physical status grade I and II.

Exclusion Criteria

• patients on any of the study drugs prior to surgery 2.
• patients having history of drug abuse 4.
• patients who are mentally retarded 5.
• coagulation defects 6.
• conditions contraindicated for induced hypotension.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
to evaluate the efficacy of intravenous dexmedetomidine, oral metoprolol as a premedicant with inhalational sevoflurane for inducing hypotension in terms of mean arterial blood pressure and surgical field visibility	baseline, every minute for first 5 minutes, every 5 minutes for next 15 minutes and then every 15 minutes till the end of surgery

Secondary Outcome Measures

Name	Time	Method
to study the incidence of intra-operative and post-operative complications associated with study drugs or technique of induced hypotension	intraoperatively and upto 24 hours after surgery

Trial Locations

Locations (1)

Sri Guru Ram das institute of Medical Sciences And Research; 🇮🇳 Amritsar, PUNJAB, India

Sri Guru Ram das institute of Medical Sciences And Research

🇮🇳Amritsar, PUNJAB, India

Dr Sunil Chawla

Principal investigator

9915530033

drchawla30@yahoo.co.in