Histological and pathophysiological investigation of hyperkeratotic hand eczema
Completed
- Conditions
- eczema hyperkeratoticum et rhagadiformehyperkeratotic hand eczema10014982
- Registration Number
- NL-OMON45756
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
- Written informed consent.
- >=18 years old.
- Hyperkeratotic hand eczema as defined by the Danish Contact Dermatitis Group
- No concomitant diagnose of atopic dermatitis (current)
Exclusion Criteria
• Immunosuppressive or immunomodulatory treatment within the last 4 weeks
• UV radiation therapy within 4 weeks before biopsy
• Active bacterial, fungal or viral infection of the hands
• Other skin diseases of the hands
• Proven contact sensitization with clinical relevance to the hands, in which exposure to allergens is not avoided
• History of psoriasis or psoriasis lesions elsewhere on the body
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>To compare the immunofluorescence profile of different keratin proteins,<br /><br>epidermal barrier proteins and adhesion molecules in the skin of patients with<br /><br>hyperkeratotic hand eczema with healthy controls </p><br>
- Secondary Outcome Measures
Name Time Method <p>- To compare lesional with non lesional skin of the palms of hyperkeratotic<br /><br>hand eczema patients<br /><br>- To describe the histopathology of hyperkeratotic hand eczema<br /><br>- To describe the ultrastructure and expression of desmosomal components of<br /><br>hyperkeratotic hand eczema compared to healthy controls</p><br>