Efficacy of zincsulfate in icter

Not Applicable

Conditions: indirect hyperbilirubinemia.
Neonatal jaundice associated with preterm delivery

Registration Number: IRCT2015120825439N1

Lead Sponsor: Birjand University of Medica Sciences

Brief Summary: Abstract Introduction and Aim: Ichter and hyperbilirubinemia are common and, in most cases, benign problems in infancy. Ichter occurs in about 60% of the term and 80% of preterm infants during the first weeks of life. Several studies conducted on the impact of zinc salts on indirect serum bilirubin levels in newborns have shown different results, all of which have called for further research. The aim of this study was to determine the effect of zinc sulfate on indirect hyperbilirubinemia in premature infants admitted to the NICU. Materials and methods: As a randomized, double-blind, clinical trial, this study was conducted in the NICU of Vali-e-Asr Hospital. The population consisted of premature infants admitted to the NICU of Vali-e-Asr Hospital. The sample included 60 infants who were randomly assigned into intervention and control groups (n=30 per group). While both groups underwent phototherapy, the intervention group received 1 cc/kg zinc sulfate syrup (containing 5 mg/5cc zinc sulfate) whereas the control group was given 2 cc/kg placebo syrup (containing sucrose) simultaneously. Assessment was made at the time of hospitalization, 6 hours later, and on a daily basis. The data were analyzed in SPSS software (version 21) using descriptive (mean, standard deviation, frequency and percentage) and inferential statistical tests (independent t-test, ANOVA, post hoc Bonferroni test, and Mann-Whitney test). P values less than or equal to 0.05 were considered significant. Findings: The study included 30 infants in the intervention group and 30 infants in the control group. There were not significant differences between the two groups in terms of gender, mean birth age at the start of phototherapy, and gestational age. Changes in bilirubin levels, respectively in intervention and control groups, 6 hours after treatment were -1.45±3.23 and -0.49±0.37 (P=0.024): at 24 hours, -3.26±2.78 and -1.89±1.20 (P0.017); and at 48 hours, -4.89±2.76 and -3.98±2.32 (P=0.23). Phototherapy time had no significant difference between the two groups (P=0.24). Conclusion: The results of this study showed that application of zinc sulfate syrup in premature infants with indirect hyperbilirubinemia within 48 hours of starting treatment could substantially reduce bilirubin levels. Key Words: Ichter; Premature Infants; Zinc Sulfate

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

inclusion criteria:premature neonate with GA30-37week;weight1500-2500 exclusion criteria:hemolysis; o sepsis;abnormality;dehydration;G6PD;ABOmissmatch;positive coombs;history of consumption phenobarbital by mother;IUGR;ventilation;NPO

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evel of bilirubin. Timepoint: 6hours/24hours/48hours. Method of measurement: mg/dl.;Time of phototherapy. Timepoint: 6hours/24hours/48hours. Method of measurement: hour.

Secondary Outcome Measures