ISRCTN02725351已完成不适用
A randomised controlled clinical trial to evaluate high dose fluconazole with or without flucytosine in the treatment of human immunodeficiency virus (HIV)-associated cryptococcal meningitis
St George's University of London (UK)0 个研究点目标入组 80 人开始时间: 2008年3月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Patients greater than 18 years, either sex
- •2. A first episode of cryptococcal meningitis
排除标准
- •1. Alanine aminotransferase (ALT) greater than five times the upper limit of normal
- •2. Pregnancy or lactation
- •3. Previous serious reaction to study drugs
- •4. Taking systemic anti-fungals
- •5. Polymorphonuclear leukocytes (PMNs) less than 500 x 10^6/L
- •6. Platelets less than 50,000 x 10^6/L
- •7. Concomitant medication that is contraindicated with any study drugs
- •8. Already on antiretroviral therapy (ART)
- •STEP 2 additional criteria:
- •9. Initial creatinine greater than 2.5 mg/dl
研究者
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