A Study to Assess All-Cause Mortality and Cardiovascular Morbidity in Participants With Chronic Kidney Disease (CKD) on Dialysis and Those Not on Renal Replacement Therapy Receiving Methoxy Polyethylene Glycol-Epoetin Beta (Mircera) or Reference Erythropoietin Stimulating Agents (ESAs)
- Conditions
- Chronic Renal Anemia
- Interventions
- Registration Number
- NCT00773513
- Lead Sponsor
- Hoffmann-La Roche
- Brief Summary
This 2 arm safety study will compare the outcome with respect to a composite endpoint of all-cause mortality and non-fatal cardiovascular events (myocardial infarction, stroke) in CKD participants either on dialysis or not receiving renal replacement therapy under treatment with methoxy polyethylene glycol-epoetin beta or reference ESAs. Participants will be randomized to receive intravenous (iv) or subcutaneous (sc) methoxy polyethylene glycol-epoetin beta at the following doses: for participants not already receiving ESA treatment, methoxy polyethylene glycol-epoetin beta will be administered at a starting dose of 0.6 micrograms per kilograms every 2 weeks (mcg/kg/2wks) iv or sc; for participants receiving maintenance ESA treatment, iv or sc methoxy polyethylene glycol-epoetin beta will be administered at an initial monthly dose of 120, 200 or 360 micrograms (mcg) depending on the weekly dose of ESA received prior to first methoxy polyethylene glycol-epoetin beta administration. Participants randomized to reference ESA treatment will receive iv or sc ESAs in accordance with their prescribed dosing information.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2825
- Male or female participants with symptomatic anemia associated with CKD
- Participants with renal anemia who are not treated with an ESA:
- Anemia was defined as hemoglobin (Hb) concentration less than (<) 11.0 grams per deciliter (g/dL) (mean of 2 screening values with at least one day and a maximum of 2 weeks between measurements) with clinical indication for ESA treatment
- Participants with renal anemia who are on maintenance ESA therapy:
- If on dialysis: regular long-term hemodialysis or peritoneal dialysis therapy with the same mode of dialysis for at least 3 months before screening
- Hb concentration between 10 and 12 g/dL (mean of 2 screening values with at least one day and a maximum of 2 weeks between measurements)
- Participants with adequate iron status defined as: serum ferritin above or equal to 100 micrograms per liter or transferrin saturation above or equal to 20 percent
- Contraindications to ESA treatment: uncontrolled hypertension, hypersensitivity to the active substance or any of the excipients, any other contraindication to ESA therapy
- Conditions known to cause inadequate response to ESA treatment or anemia other than symptomatic anemia associated with CKD:
- History of hemoglobinopathy
- Anemia due to hemolysis
- Pure red cell aplasia
- High likelihood of early withdrawal (for example, within 1 year) or interruption of the study
- Pregnancy or breast-feeding
- Women of childbearing potential without effective contraception
- Administration of another investigational drug within 1 month before screening or planned during the study period
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Methoxy Polyethylene Glycol-Epoetin Beta Epoetin Alfa Participants not currently being treated with an ESA will receive methoxy polyethylene glycol-epoetin beta iv or sc once every 2 weeks for correction of renal anemia (target Hb 10-12 g/dL). Once corrected and in participants currently being treated with an ESA, methoxy polyethylene glycol-epoetin beta will be administered once monthly. Erythropoiesis Stimulating Agents Epoetin Alfa Participants will receive reference ESA according to approved label. The approved reference ESA compounds in the study will be darbepoetin alfa, epoetin alfa and epoetin beta. Erythropoiesis Stimulating Agents Darbepoetin Alfa Participants will receive reference ESA according to approved label. The approved reference ESA compounds in the study will be darbepoetin alfa, epoetin alfa and epoetin beta. Erythropoiesis Stimulating Agents Epoetin Beta Participants will receive reference ESA according to approved label. The approved reference ESA compounds in the study will be darbepoetin alfa, epoetin alfa and epoetin beta. Methoxy Polyethylene Glycol-Epoetin Beta Darbepoetin Alfa Participants not currently being treated with an ESA will receive methoxy polyethylene glycol-epoetin beta iv or sc once every 2 weeks for correction of renal anemia (target Hb 10-12 g/dL). Once corrected and in participants currently being treated with an ESA, methoxy polyethylene glycol-epoetin beta will be administered once monthly. Erythropoiesis Stimulating Agents methoxy polyethylene glycol-epoetin beta Participants will receive reference ESA according to approved label. The approved reference ESA compounds in the study will be darbepoetin alfa, epoetin alfa and epoetin beta. Methoxy Polyethylene Glycol-Epoetin Beta methoxy polyethylene glycol-epoetin beta Participants not currently being treated with an ESA will receive methoxy polyethylene glycol-epoetin beta iv or sc once every 2 weeks for correction of renal anemia (target Hb 10-12 g/dL). Once corrected and in participants currently being treated with an ESA, methoxy polyethylene glycol-epoetin beta will be administered once monthly.
- Primary Outcome Measures
Name Time Method Time to Composite of All-Cause Mortality and Non-Fatal Cardiovascular Events (Myocardial Infarction, Stroke) Defined as Time Between First Dose of Study Medication and Date of Death or Non-Fatal Cardiovascular Events, Whichever Occurred First Baseline up to approximately 8.5 years
- Secondary Outcome Measures
Name Time Method Percentage of Participants With Gastrointestinal Bleeding Baseline up to approximately 8.5 years Time to Non-Fatal and Fatal Stroke Baseline up to approximately 8.5 years Time to Non-Fatal Cardiovascular Events (Myocardial Infarction or Stroke, Whichever Occurred First) Baseline up to approximately 8.5 years Percentage of Participants With Anti-Erythropoietin Antibody-Mediated Pure Red Cell Aplasia (PRCA) Baseline up to approximately 8.5 years Time to All-Cause Mortality Baseline up to approximately 8.5 years Time to Non-Fatal and Fatal Myocardial Infarction Baseline up to approximately 8.5 years Percentage of Participants With Thromboembolic Events Baseline up to approximately 8.5 years
Trial Locations
- Locations (196)
Gosford Hospital; Renal
🇦🇺Gosford, New South Wales, Australia
General Hospital Josip Bencevic; Department of Haemodialysis
🇭🇷Slavonski Brod, Croatia
Renal Research Dr Simon Roger
🇦🇺Gosford, New South Wales, Australia
Hospital Sao Lucas - PUCRS
🇧🇷Porto Alegre, RS, Brazil
Centre Hospitalier; Hemodialyse
🇫🇷Annonay, France
Royal Perth Hospital; Nephrology
🇦🇺Perth, Western Australia, Australia
UZ Leuven Gasthuisberg
🇧🇪Leuven, Belgium
Centro Mineiro de Pesquisa - CMIP
🇧🇷Juiz de Fora, MG, Brazil
Gold Coast Hospital Department of Pharmacology & Therapeutics
🇦🇺Southport, Queensland, Australia
Centre Hospitalier Uni Ire Gaston Doumergue; Service D'Hemodialyse
🇫🇷Nimes, France
Hopital Civil; Nephrologie Clinique Medicale B
🇫🇷Strasbourg, France
Gemeinschaftspraxis Dr. Stefan Zinn und Steffen Hengst
🇩🇪Alsfeld, Germany
Nemocnice Strahov; Interni Oddeleni-Strahov
🇨🇿Praha 6, Czechia
Aura - Centre Henri Kunt Ziger
🇫🇷Paris, France
Institut Klinicke A Experimentalni Mediciny Klinika Nefrologie
🇨🇿Praha, Czechia
Aural
🇫🇷Lyon, France
Klinikum Hann. Münden, Nephrologisches Zentrum Niedersachsen
🇩🇪Hann. Münden, Germany
Hopital Rangueil; Nephrologie Hemodialyse
🇫🇷Toulouse, France
DaVita Clinical Research Deutschland GmbH
🇩🇪Düsseldorf, Germany
Georg-Haas-Dialysezentrum der PHV
🇩🇪Gießen, Germany
KfH Kuratorium für Dialyse und Nierentransplantation e.V.; KfH-Nierenzentrum
🇩🇪München, Germany
Ospedale Bernardo Ramazzi; U.O. Di Nefrologia E Dialisi
🇮🇹Carpi, Emilia-Romagna, Italy
University Hospital Coventry And Warwickshire Nhs Trust; Department Of Nephrology
🇬🇧Coventry, United Kingdom
Ospedale Civile; Divisione de Nefrologia E Dialisi
🇮🇹Piacenza, Emilia-Romagna, Italy
Hospital Ramon y Cajal; Servicio de Nefrologia
🇪🇸Madrid, Spain
Presidio Ospedaliero Maggiore Policlinico Fondazione IRCCS; Pad Croff Div Nefrologia Dialisi
🇮🇹Milano, Lombardia, Italy
Ospedale S. Marta S. Venera Nuovo; U.O. Nefrologia Dialisi
🇮🇹Acireale, Sicilia, Italy
Uppsala University Hospital; Department of Internal Medicine, Nephrology Section
🇸🇪Uppsala, Sweden
Ulster Hospital; Nephrology
🇬🇧Belfast, United Kingdom
Hospital Clinico San Carlos; Servicio de Nefrologia
🇪🇸Madrid, Spain
Hospital de Cruces; Servicio de Nefrologia
🇪🇸Barakaldo, Vizcaya, Spain
Hospital del Mar; Servicio de Nefrologia
🇪🇸Barcelona, Spain
Hospital Txagorritxu; Servicio de Nefrologia
🇪🇸Vitoria, Alava, Spain
Hospital de Navarra; Servicio de Nefrologia
🇪🇸Pamplona, Navarra, Spain
Hospital Infanta Sofia; Servico de Nefrologia
🇪🇸San Sebastian de los Reyes, Madrid, Spain
King Chulalongkorn Memorial Hospital; Renal Unit, Department of Medicine
🇹🇭Bangkok, Thailand
Danderyds Sjukhus; Dept. of Nephrology
🇸🇪Danderyd, Sweden
University Hospital of Wales; Institute of Nephrology
🇬🇧Cardiff, United Kingdom
Dorset County Hospital; Renal Unit
🇬🇧Dorchester, United Kingdom
Royal Devon & Exeter Hospital; Dept of Nephrology
🇬🇧Exeter, United Kingdom
Hospital Universitario San Cecilio
🇪🇸Granada, Spain
St James Uni Hospital; Renal Unit
🇬🇧Leeds, United Kingdom
James Cook Hospital; Nephrology
🇬🇧Middlesborough, United Kingdom
Salford Royal Foundation Trust; Department Of Nephrology
🇬🇧Salford, United Kingdom
Morriston Hospital; Renal Medicine
🇬🇧Swansea, United Kingdom
Belfast City Hospital; Nephrology Unit
🇬🇧Belfast, United Kingdom
Hull Royal Infirmary; Renal Medicine
🇬🇧Hull, United Kingdom
St Helier Hospital; Renal Unit
🇬🇧Carshalton, United Kingdom
Derriford Hospital; Department Of Renal Medicine
🇬🇧Plymouth, United Kingdom
St Luke'S Hospital; Renal Unit
🇬🇧Bradford, United Kingdom
Fresenius Medical Care Martinez
🇦🇷Buenos Aires, Argentina
Monash Medical Centre; Renal Transplant Unit
🇦🇺Clayton, Victoria, Australia
General Hospital Karlovac; Dept of Haemodialysis
🇭🇷Karlovac, Croatia
Clinical Hospital Center Rijeka; Dialysis
🇭🇷Rijeka, Croatia
General Hospital Zadar; Dialysis
🇭🇷Zadar, Croatia
Clinique Lambert; Service de Néphrologie dialyse
🇫🇷La Garenne-Colombes, France
Sheba MC; Nephrology
🇮🇱Ramat-Gan, Israel
Ospedale Provinciale S. Maria delle Croci; Divisione Nefrologia e Dialsi
🇮🇹Ravenna, Emilia-Romagna, Italy
A.O. Santa Maria Nuova Di Reggio Emilia; Unita Operativa Di Nefrologia E Dialisi
🇮🇹Reggio Emilia, Emilia-Romagna, Italy
ASST SANTI PAOLO E CARLO; U.O.S. Nefrologia e Dialisi
🇮🇹Milano, Lombardia, Italy
Ospedale S. Giacomo; U.O. Di Nefrologia e Dialisi
🇮🇹Castelfranco, Veneto, Italy
Az. Osp. Di Padova; U.O. Nefrologia 2 E Dialisi
🇮🇹Padova, Veneto, Italy
Centro Especializado San Fernando; Nefrología, Diálisis y Trasplante Renal
🇵🇦Panama, Panama
NZOZ Stacja Dializ Hand-Prod w Gorlicach
🇵🇱Gorlice, Poland
Fresenius Nephrocare Polska Sp. z o.o., Centrum Dializ Fresenius, Osrodek Dializ nr 53 w Pabianicach
🇵🇱Pabianice, Poland
Fresenius Nephrocare Polska Sp. z o.o., Centrum Dializ Fresenius, Osrodek Dializ numer 71 w Poznaniu
🇵🇱Poznan, Poland
Fresenius Nephrocare Polska Sp.zo.o.Centrum Dializ FreseniusOśrodek Dializ Nr 62 w Sandomierzu
🇵🇱Sandomierz, Poland
Clinical Hospital Center Zvezdara
🇷🇸Belgrade, Serbia
Hospital Severo Ochoa; Servicio de Nefrologia
🇪🇸Leganes, Madrid, Spain
Complejo Hospitalario de Jaen- Hospital Universitario Medico Quirurgico
🇪🇸Jaen, Spain
Maelar Hospital; Department of Medicine
🇸🇪Eskilstuna, Sweden
Chang Gung Medical Fundation Kaohsiung Branch; Nephrology
🇨🇳Kaohsiung, Taiwan
Maharaj Nakorn Chiang Mai Hospital; Dept. of Medicine, Renal Division
🇹🇭Chiang Mai, Thailand
Buddhachinaraj Hospital Renal Division; Dept of Medicine
🇹🇭Phitsanulok, Thailand
Leicester General Hospital; Dept of Nephrology
🇬🇧Leicester, United Kingdom
The Ipswich Hospital Nhs Trust; The Renal Unit
🇬🇧Ipswich, United Kingdom
Freeman Hospital; Nephrology
🇬🇧Newcastle Upon Tyne, United Kingdom
Royal Free & University College Medical School; Centre for Nephrology
🇬🇧London, United Kingdom
The Churchill; Oxford Kidney Unit
🇬🇧Oxford, United Kingdom
Royal Preston Hospital; Department of Renal Medicine
🇬🇧Preston, United Kingdom
Royal Shrewsbury Hospital
🇬🇧Shrewsbury, United Kingdom
Royal Cornwall Hospital; Renal Unit
🇬🇧Truro, United Kingdom
Worthing Hospital; Renal Unit
🇬🇧West Sussex, United Kingdom
Santa Casa de Misericordia de Porto Alegre
🇧🇷Porto Alegre, RS, Brazil
KFH Nierenzentrum Bad Hersfeld; Nephrologie
🇩🇪Bad Hersfeld, Germany
Clinica de Medicina Interna e Nefrologia (CMIN)
🇧🇷Sao Paulo, SP, Brazil
Hopital La Cavale Blanche; Nephrologie
🇫🇷Brest, France
Centre Hospitalier Les Chanaux; Service de Néphrologie Unité 12
🇫🇷Macon, France
Hopital Laennec; Echo
🇫🇷Saint Herblain, France
Universitätsklinikum Erlangen; Medizinische Klinik 4; Nephrologie und Hypertensiologie
🇩🇪Erlangen, Germany
Praxis Dr.med. Joachim Leicht
🇩🇪Schwandorf, Germany
Launceston General Hospital; Diabetes and Renal Research Unit
🇦🇺Launceston, Tasmania, Australia
Jessa Zkh (Campus Virga Jesse)
🇧🇪Hasselt, Belgium
AZ Delta (Campus Wilgenstraat)
🇧🇪Roeselare, Belgium
ROYAL ADELAIDE HOSPITAL; Renal Clinical Trials, CNARTS
🇦🇺Adelaide, South Australia, Australia
UZ Brussel
🇧🇪Brussel, Belgium
UZ Gent
🇧🇪Gent, Belgium
Cairns Hospital; Renal Services
🇦🇺Cairns, Queensland, Australia
Fresenius Medical Care Morón
🇦🇷Buenos Aires, Argentina
Fresenius Medical Care San Martin
🇦🇷Buenos Aires, Argentina
Fresenuis Medical Care Mansilla
🇦🇷Caba, Argentina
Hospital Univ. Pedro Ernesto - Hupe; Nefrologia
🇧🇷Rio de Janeiro, RJ, Brazil
Hospital das Clinicas - FMUSP; Nefrologia
🇧🇷Sao Paulo, SP, Brazil
Clinical Hospital Osijek; Dept of Haemodialysis
🇭🇷Osijek, Croatia
Klinicki Bolnicki Centar Zagreb; Dialysis
🇭🇷Zagreb, Croatia
KFH Nierenzentrum Oberschleissheim
🇩🇪Oberschleissheim, Germany
Hippokratio Hospital; Nefrology
🇬🇷Thessaloniki, Greece
Rabin MC- Hasharon campus
🇮🇱Petah Tikva, Israel
Universita' Di Tor Vergata; Clinica Nefrologia Dialisi
🇮🇹Roma, Lazio, Italy
ASST GRANDE OSPEDALE METROPOLITANO NIGUARDA; Dipartimento di Nefrologia e Dialisi
🇮🇹Milano, Lombardia, Italy
Hospital of Lithuanian University of Health. Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
National Kidney and Transplant Institute
🇵🇭Quezon City, Philippines
Fresenius Nephrocare Polska Sp zo.o. Centrum Dializ Fresenius Osrodek Dializ Nr 42 w Jasle
🇵🇱Jaslo, Poland
Powiatowy Szpital Specjalistyczny w Stalowej Woli; Oddział Nefrologii i Dializoterapii
🇵🇱Stalowa Wola, Poland
S.P. Szpital Wojewodzki im. Papieza Jana Pawla II
🇵🇱Zamosc, Poland
National University Hospital; Dept of Medicine
🇸🇬Singapore, Singapore
A.O. Cà Foncello; U.O.Nefrologia, Dialisi e Centro Trapianti
🇮🇹Treviso, Veneto, Italy
Hopital Edouard-Herriot; Nephrologie - Hemodialyse
🇫🇷Lyon, France
PUCPR
🇧🇷Curitiba, PR, Brazil
Beneficencia Portuguesa de Sao Paulo
🇧🇷Sao Paulo, SP, Brazil
Hopital Louis Pasteur; Nephrologie - Hemodialyse
🇫🇷Colmar, France
Universidade Federal de Sao Paulo - UNIFESP
🇧🇷Sao Paulo, SP, Brazil
Instituto de Hemodialise Sorocaba
🇧🇷Sorocaba, SP, Brazil
Service de Nephrologie & D'Immunologie; Clinique
🇫🇷Nantes, France
Clinical Hospital Split; Dialysis
🇭🇷Split, Croatia
Hopital Pellegrin; Departement Nephrologie
🇫🇷Bordeaux, France
Centre Hospitalier Du Dr Duchenes; Service De Nephrologie & Hemodialyse
🇫🇷Boulogne, France
Chu Dupuytren; Nephrologie-Hemodialyse
🇫🇷Limoges, France
Hopital Sud ; Nephrologie Hemodialyse
🇫🇷Salouel, France
Ch De Valenciennes; Nephrologie
🇫🇷Valenciennes, France
Universitätsklinikum Bonn; Medizinische Klinik und Poliklinik I; Allgemeine Innere Medizin
🇩🇪Bonn, Germany
Uniklinikum Heidelberg
🇩🇪Heidelberg, Germany
Dres. Roland Erwin Winkler Ann Michelsen Dietmar Sehland u.w.
🇩🇪Rostock, Germany
Azienda Ospedaliera San Salvatore; Divisione Nefrologia E Dialisi
🇮🇹Pesaro, Marche, Italy
Dialysepraxis Dr. med. Uwe Kraatz
🇩🇪Demmin, Germany
Universitaetsklinikum des Saarlandes; Klinik f. Innere Medizin IV
🇩🇪Homburg/Saar, Germany
Robert-Bosch-Krankenhaus; Allgemeine Innere Medizin und Nephrologie
🇩🇪Stuttgart, Germany
Uni Hospital of Alexandroupoli; Nephrology Dept.
🇬🇷Alexandroupolis, Greece
Rabin MC- Belinson campus
🇮🇱Petach Tikva, Israel
Sourasky MC; Dept. of Nephrology
🇮🇱Tel Aviv, Israel
ASST DI LECCO; Nefrologia e Dialisi
🇮🇹Lecco, Lombardia, Italy
Nuovo Ospedale Di Prato
🇮🇹Prato, Toscana, Italy
Selayang Hospital; Dept of Medicine
🇲🇾Selangor, Malaysia
Wojewodzki Szpital Zespolony, Stacja Dializ, Skierniewice
🇵🇱Skierniewice, Poland
Seoul National Uni Hospital; Internal Medicine
🇰🇷Seoul, Korea, Republic of
Universitätsklinikum Duesseldorf; Klinik fuer Nephrologie
🇩🇪Düsseldorf, Germany
UNI-Klinikum Campus Kiel Klinik f.Innere Medizin IV
🇩🇪Kiel, Germany
Laiko General Hospital; Nephrology Div.
🇬🇷Athens, Greece
Uni Hospital of Ioannina; Nephrology Dept.
🇬🇷Ioannina, Greece
Azienda Ospedaliera Sant'Anna Unità Operativa Complessa di Nefrologia Dialisi
🇮🇹Cona (FE), Veneto, Italy
Nephrologische Schwerpunktpraxis; Hamburg Barmbek
🇩🇪Hamburg, Germany
Azienda Ospedaliera Santa Maria Misericordia; Divisione Nefrologia Dialisi
🇮🇹Rovigo, Veneto, Italy
University Malaya Medical Centre; Division of Nephrology, Department of Medicine
🇲🇾Kuala Lumpur, FED. Territory OF Kuala Lumpur, Malaysia
Specjalistyczny Szpital Wojewodzki w Ciechanowie; Oddzial Nefrologiczny
🇵🇱Ciechanow, Poland
Fresenius Nephrocare Polska Sp zo.o.Centrum Dializ Fresenius Osrodek Dializ Nr 45 w Dabrowie Tarn
🇵🇱Dabrowa Tarnowska, Poland
Ospedale Civile; Servizio Di Nefrologia E Dialisi
🇮🇹Imola, Emilia-Romagna, Italy
Univeristy Hospital of Larissa; Nephrology
🇬🇷Larissa, Greece
Assaf-Harofeh MC; Nephrology
🇮🇱Zrifin, Israel
Fondazione Salvatore Maugeri; Divisione Di Nefrologia E Dialisi
🇮🇹Pavia, Lombardia, Italy
A.O. Universitaria S. Martino Di Genova; Nefrologia
🇮🇹Genova, Liguria, Italy
Ospedale Caduti Bollatesi; U.O. Nefrologia E Dialisi
🇮🇹Bollate, Lombardia, Italy
ASST LARIANA; Divisione di Nefrologia e Dialisi
🇮🇹S Fermo Della Battaglia, Lombardia, Italy
Azienda Ospedaliera Cannizzaro Unità Operativa Nefrologia
🇮🇹Catania, Sicilia, Italy
A.O.U. Policlinico G.Martino; U.O.C. Nefrologia e Dialisi
🇮🇹Messina, Sicilia, Italy
Vilnius University Hospital Santariskiu Clinic, Nephrology Center
🇱🇹Vilnius, Lithuania
Investigación Nefrológica S.C.
🇲🇽Cuernavaca, Morelos, Mexico
Presidio Ospedaliero Di Lodi; U.O. Nefrologia E Dialisi
🇮🇹Lodi, Toscana, Italy
P.O. Di Conegliano; U.O. Di Nefrologia E Dialisi
🇮🇹Conegliano, Veneto, Italy
Samsung Medical Center; Nephrology Department
🇰🇷Seoul, Korea, Republic of
Hospital Kuala Lumpur; Department of Medicine
🇲🇾Kuala Lumpur, Malaysia
NZOZ Stacja Dializ Hand-Prod w Limanowej
🇵🇱Limanowa, Poland
Clinical Center Voivodina; Clinic for Immunology and Nephrology
🇷🇸Novi Sad, Serbia
Cebu Doctors University Hospital
🇵🇭CEBU City, Philippines
Akademia Medyczna; Klinika Nefrologii I Chorob Wewnetrznych
🇵🇱Bydgoszcz, Poland
Stacja Dializ NZOZ Centrum Medyczne MEDYK
🇵🇱Rzeszow, Poland
Specjalistyczny Szpital im A.Sokołowskiego w Wałbrzychu; Oddzial Nefrologiczny
🇵🇱Walbrzych, Poland
SBEI of HPE "Northwestern State Medical University n.a. I.I.Mechnikov" of MoH of RF
🇷🇺Saint-Petersburg, Russian Federation
SBEI HPE "The First St.Petersburg State Medical University n.a. acad. I.P.Pavlova"of MoH of RF
🇷🇺Sankt-peterburg, Leningrad, Russian Federation
St.Petersburg State Budget Institution of Healthcare "City Hospital Saint Hosiomartyr Elisabeth".
🇷🇺St.Petersburg, Russian Federation
Clinical Center of Serbia; Clinic of Urology
🇷🇸Belgrade, Serbia
Zemun Hospital; Nephrology
🇷🇸Belgrade, Serbia
Clinical Center Nis; Clinic for Nephrology and Hemodialysis
🇷🇸NIS, Serbia
St.Petersburg State Budget Institution of Healthcare "City Mariinskaya Hospital"
🇷🇺St.Petersburg, Russian Federation
Singapore General Hospital; Renal Medicine
🇸🇬Singapore, Singapore
Tan Tock Seng Hospital; Department of Renal Medicine
🇸🇬Singapore, Singapore
Inonu Uni School of Medicine
🇹🇷Malatya, Turkey
National Taiwan Uni Hospital; Nephrology Dept
🇨🇳Taipei, Taiwan
Complejo Hospitalario Torrecardenas; Servicio de Nefrologia
🇪🇸Almería, Almeria, Spain
Cukurova University School of Medicine; Nefrology Department
🇹🇷Adana, Turkey
Baskent University Hospital; Transplantation
🇹🇷Ankara, Turkey
Hospital de Basurto; Servicio de Nefrologia
🇪🇸Bilbao, Vizcaya, Spain
Hospital de Galdakano; Servicio de Nefrologia
🇪🇸Galdakao, Vizcaya, Spain
Fakultni Nemocnice Kralovske Vinohrady (FNKV); Interni Hematologicka Klinika
🇨🇿Hradec Kralove, Czechia
Faculty Hospital; Dialysis Unit
🇨🇿Ostrava, Czechia
A.O. Universitaria Policlinico Di Modena; Nefrologia E Dialisi
🇮🇹Modena, Emilia-Romagna, Italy
Ospedale Maggiore; U.O.Complessa di Nefrologia e Dialisi
🇮🇹Parma, Emilia-Romagna, Italy