NCT02141139Unknown3 期
Suppression of Inflammation by Using NSAIDs During Peri-operative Period Can Affect the Prognosis of Breast Cancer.
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 入组人数
- 1,568
- 试验地点
- 1
- 主要终点
- disease free survival
研究概览
简要总结
It is increasingly recognized the NSAIDS (nonsteroidal antiinflammatory drug) might prevent the several cancers. In breast cancer, the role of NSAIDS (nonsteroidal antiinflammatory drug) has been suggested.However, there was no consistent results. surgery is main cause of inflammation for cancer patients. Therefore, we want to know the association between prevention of perioperative inflammation with NSAIDS and breast cancer outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Breast cancer patients who took the surgery
排除标准
- •underlying medical disease (major heart disease, lung disease, coagulopathy)
- •major psychologic disease (major depression, schizophrenia, manic disorder)
- •pregnancy
- •rheumatic disease patients
研究组 & 干预措施
NSAIDS (ketorolac intravenous, ibuprofen)
Experimental
ketorolac IV (just before surgery) and ibuprofen for 1 weeks
干预措施: NSAIDS (ketorolac and ibuprofen) (Drug)
结局指标
主要结局
disease free survival
时间窗: 5 years
次要结局
- overall survival(5years)
研究者
Seok Jin Nam
Professor
Samsung Medical Center
研究点 (1)
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