Influence of Therapeutic Magnesium on Platelet Function Testing
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- PAC-t-UB test results
研究概览
简要总结
Magnesium has built up the reputation of a 'natural calcium antagonist'. However, the exact effect of magnesium on coagulation and more specifically on platelet function is still disputed. An important discrepancy between in vivo and in vitro studies exists. Magnesium has thus been reported to antagonize platelets in some studies, and to stimulate platelets in other studies. Current evidence seems to point in the direction of a general antagonization of aggregation and coagulation.
Intravenous magnesium is often administered in pre-eclampsia as seizure prophylaxis. Therapeutic regimens usually consist of an intravenously administered loading dose (2-3 grams) and a maintenance infusion, targeting a plasma level of 2-3 mmol/L. Therapeutic drug monitoring is needed, as magnesium toxicity is an important concern.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Signed Informed consent
- •Over 18 years of age (and younger or equal to 50 years of age) and able to provide legally binding consent
- •American Society of Anesthesiologists physical fitness scale 1 (non smoker, no or minimal alcohol use, ..)
排除标准
- •Chronic disease
- •Chronic medical therapy (other than oral contraception)
- •Pregnancy
- •ASA 2 or higher
- •Known coagulation or aggregation disorders
- •Use of COX-inhibitors in the last 10 days
- •Contra-indications for venipuncture
结局指标
主要结局
PAC-t-UB test results
时间窗: 4 months
The main endpoint of this study is the Platelet Activation Test in Unprocessed Blood (PAC-t-UB).
次要结局
未报告次要终点
研究者
Dieter Mesotten
MD
Ziekenhuis Oost-Limburg